报告人： Professor Guijun Wang

Guijun Wang, Department of Chemistry and Biochemistry, Old Dominion University

题目：Synthesis of Chiral Small Molecules for Drug Discovery and Study of Carbohydrate Based Advanced Materials

时间：2015年5月22日（星期五）10:00am

地点：独墅湖校区909号楼B厅

摘要：

Chiral small molecules are important for the synthesis of medicinally relevant compounds and for the preparation of advanced materials. Carbohydrates are abundant and renewable natural resources. Sugars contain multiple chiral centers and can be selectively functionalized to produce interesting new materials or biologically active compounds. For the past several years, my group has been working on the synthesis of chiral heterocycles and natural product analogs and the design and synthesis of carbohydrate based advanced soft biomaterials. We have carried out the synthesis and characterizations of various monosaccharide derivatives and discovered several novel classes of sugar based low molecular weight gelators (LMWGs). These compounds form unique reversible supramolecular organogels and hydrogels that are useful in biomedical research and as advanced functional materials. In this seminar, I will give a brief overview of our ongoing research. After that our resent research for the synthesis of chiral amines and heterocycles will be discussed, followed by the synthesis and characterization of new D-glucose and D-glucosamine based molecular gelators.

个人简介：

Work history:

2014.5 � present: Professor of Chemistry and Biochemistry, Old Dominion University

2012.8 � 2014-4: Associate Professor of Chemistry and Biochemistry, Old Dominion University

2006.8 � 2012.7:  Associate Professor of Chemistry, University of New Orleans

2002.8 � 2006.7:  Assistant Professor of Chemistry, University of New Orleans

2000.7 � 2002.7:  Postdoctoral Research Associate, Yale University 

1999.5 � 2000.6:  Postdoctoral Research Associate, Michigan State University 

1993.5 � 1995.5:  Instructor, Department of Chemistry, Tsinghua University, Beijing, China

Degrees:

1999: Ph.D. Organic Chemistry, Michigan State University, East Lansing, MI, USA

1993: M.S. Structural Chemistry, Tsinghua University, Beijing, China

1990: B.S. Chemistry, Tsinghua University, Beijing, China

Research interests:

Synthetic organic chemistry, asymmetric catalysis, synthesis of biologically active compounds, medicinal chemistry, carbohydrate chemistry, biomaterials and supramolecular chemistry, the ongoing projects include:

• ―Synthetic methodology development, catalytic reactions
• ―Synthesis of natural products and their analogs for drug discovery
• ―Synthesis and study of glycoconjugates and glycomemitics

联络人：孙旭辉、樊建教授