题目：

Photoactivated H₂ Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

作者：

Rui Sun,¹ Xiaocen Liu,¹ Guangzhi Li,^1,2 Hui Wang,^1,2 Yongxiang Luo,¹ Guixiao Huang,¹ Xisheng Wang,³ Guohua Zeng,⁴ Zhuang Liu^5,* and Song Wu^1,6,*

单位：

¹Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen 518000, China

²Liaoning Key Laboratory of Proteomics, Dalian Medical University, Dalian 116044, China

³Department of Urology, Longhua District Central Hospital, Shenzhen 518110, China

⁴Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

⁵Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University Suzhou, Jiangsu 215123, China

⁶Department of Urology, The Second Hospital of Lanzhou University, Lanzhou 730030, China

摘要：

Hydrogen gas can mitigate oxidative stress in many diseases and is regarded to be safe and free of side effects. Inspired by a metalloenzyme in a variety of microorganisms, here, we propose a photoactivated H₂ nanogenerator that comprises a fluorinated chitosan (FCS), a chemotherapeutic drug (gemcitabine, GEM), and a catalyst of H₂ production ([FeFe]TPP) that can form self-assembled [FeFe]TPP/GEM/FCS nanoparticles (NPs). The [FeFe]TPP/GEM/FCS NPs exhibit excellent transmucosal and tumor cell penetration capacities after intravesical instillation into the bladder and can efficiently produce H₂ gas in situ upon 660 nm laser irradiation, which significantly enhances the efficacy of hydrogen chemotherapy of cancer in vitro and in vivo. Moreover, we discover that H₂ gas in hydrogen chemotherapy can inhibit mitochondrial function, hinder ATP synthesis, and cause a reduction of the P-gp efflux pump function, which finally attenuates P-gp protein drug transport capacity in cancer cells. This photoactivated H₂ evolution in situ to improve the therapeutic efficacy of chemotherapy of bladder cancer may present an effective hydrogen chemotherapy strategy for cancer treatment.

影响因子：

14.588

分区情况：

一区

链接：

https://pubs.acs.org/doi/abs/10.1021/acsnano.0c01300

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