English 
     
   首 页
   热点信息
语言中心主任致辞
培养方案
专业介绍
招生问答
我院近期科研成果被国际学术...
联系我们
纳米科学技术学院2012年招生...
学生工作办公室简介
请加QQ群312279505
刘坚教授课题组在Adv. Funct. Mater.上发表论文
发布时间:2021-10-25 点击:11

题目:

Triggering Reactive Oxygen Species Field Effect Transistor Based on HIF-1α Signaling for Enhanced Chemodynamic Therapy


作者:

Zhihao Zhao,1 Jun Yan,1 Ke Ling,1 Rui Shi,1 Rui Lv,1 Baoqing Nie,2 and Jian Liu1,*


单位:

1Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China

2School of Electronic and Information Engineering, Soochow University, Suzhou 215006, China


摘要:

A hypoxic tumor microenvironment (TME) makes tumors resistant to various therapies including chemotherapies, radiotherapies, and photodynamic therapies. Here, a new strategy of building a reactive oxygen species (ROS) field effect transistor (FET) is reported, which enables amplified ROS flux for tumor ablation and addresses the challenge of tumor hypoxia by a liposomal delivery system (SN-38LP@Fe3O4/GOx). This design can switch ON the ROS FET by a small tuning on the “gate electrode” with downregulation of HIF-1α signaling. Highly effective tumor ablation both in vitro and in vivo using the ROS FET strategy is demonstrated, and its mechanism of changing tumor hypoxia is revealed. Distinctly different from the previous reports based on the chemical supply to address hypoxia TME, this work conceptually creates a method of maximizing ROS damages for cancer treatment with well-leveraged modulation of the tumor hypoxia pathways.


影响因子:

16.836


分区情况:

一区


链接:

https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202106471


责任编辑:向丹婷


Copyright © 2012 苏州大学纳米科学技术学院 All Rights Reserved.
  地址:苏州工业园区仁爱路199号910楼  邮编:215123
您是第 位访问者