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刘庄教授课题组与程亮教授课题组合作在ACS Nano上发表论文
发布时间:2021-03-18 点击:21

题目:

Ultrasmall Iron-Doped Titanium Oxide Nanodots for Enhanced Sonodynamic and Chemodynamic Cancer Therapy

作者:

Shang Bai, Nailin Yang, Xianwen Wang, Fei Gong, Ziliang Dong, Yuehan Gong, Zhuang Liu*, and Liang Cheng*

单位:

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for

Carbon Based Functional Materials and Devices, Soochow University, Suzhou 215123, 

People’s Republic of China

摘要:

Sonodynamic therapy (SDT), which can generate reactive oxygen species (ROS) based on sonosensitizers under ultrasound (US) to kill tumor cells, has emerged as a noninvasive therapeutic modality with high tissue-penetration depth. Herein, ultrasmall iron-doped titanium oxide nanodots(Fe-TiO2 NDs) are synthesized via a thermal decomposition strategy as a type of sonosensitizers to enhance SDT. Interestingly, the Fe doping in this system appears to be crucial in not only enhancing the US-triggered ROS generation of those NDs but also offering NDs the Fenton-catalytic function to generate ROS from tumor endogenous H2O2 for chemodynamic therapy (CDT). After polyethylene glycol (PEG) modification, Fe-TiO2-PEG NDs demonstrate good physiological stability and biocompatibility. With efficient tumor retention after intravenous injection as revealed by in vivo magnetic resonance (MR) and fluorescent imaging, our Fe-TiO2 NDs demonstrate much better in vivo therapeutic performance than commercial TiO2 nanoparticles owing to the combination of CDT and SDT. Moreover, most of those ultrasmall Fe-TiO2 NDs can be effectively excreted within one month, rendering no obvious long-term toxicity to the treated mice. Our work thus presents a type of multifunctional sonosensitizer for highly efficient cancer treatment via simply doping TiO2 nanostructures with metal ions.

影响因子:

14.588

分区情况:

一区

链接:

 https://dx.doi.org/10.1021/acsnano.0c05235


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