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南开大学生命科学学院丁丹教授 7月28日上午学术报告
发布时间:2017-7-24 10:24:28 点击:

Presenter: 丁丹(南开大学生命科学学院、药物化学生物学国家重点实验室、生物活性材料教育部重点实验室教授)

Topic: Design, Synthesis and Biomedical Application of New Fluorescent Probes

Time: 10:00 AM, Jul. 28th (Friday)

Location: Conference Room B, BLDG 909-1F

 

Abstract

Development of efficient fluorescent probes with intense far-red/near-infrared (FR/NIR) emission (> 650 nm) is of great importance in biosensing and bioimaging research. To date, a large variety of materials, including organic dyes, fluorescent proteins and inorganic quantum dots (QDs), has been extensively studied for the purpose of FR/NIR fluorescence imaging. Organic dyes and fluorescent proteins, however, suffer from limited molar absorptivity and low photobleaching thresholds, while inorganic QDs are highly cytotoxic in an oxidative environment: this has greatly limited the scope of their in vitro and in vivo applications. Exploration of novel FR/NIR fluorescent probes with a high biological compatibility, strong photobleaching resistance, and efficient light emission is highly desirable for biosensing and bioimaging. Herein, we designed and synthesized new FR/NIR fluorescent probes based on semiconducting polymers, fluorophores with aggregation-induced emission (AIE) characteristics or environment-sensitive fluorophores. We then explored the biomedical applications of these new fluorescent probes, which were demonstrated as very promising probes for in vitro and in vivo biosensing and bioimaging applications. 

 

Biography

丁丹,男,19828月出生,南开大学生命科学学院、药物化学生物学国家重点实验室、生物活性材料教育部重点实验室教授。课题组的研究方向为新型分子影像材料的制备与生物医学应用。2013年以来,丁丹先后入选了天津市青年千人计划、南开大学百名青年学科带头人计划、天津市青年科技优秀人才等人才计划,并于2016年获得了国家自然科学基金委优秀青年科学基金项目的资助。迄今为止,丁丹以通讯作者或第一作者在Accounts of Chemical ResearchAdvanced MaterialsACS Nano等重要国际期刊上发表了SCI论文近50篇。研究成果受到国内外同行专家的广泛关注,SCI 论文共被他人引用2000余次,H-index29

 

Contact: Prof. Lichen Yin

 

责任编辑:杨娟



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