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刘庄教授课题组在National Science Review上发表特邀综述
发布时间:2017-9-13 22:04:05 点击:

题目:

The Acidic Tumor Microenvironment: A Target for Smart Cancer Nano-Theranostics


作者:

Liangzhu Feng, Ziliang Dong, Danlei Tao, Yicheng Zhang and Zhuang Liu


单位:

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Jiangsu 215123, China


摘要:

The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article, we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards.


影响因子:

8.843


分区情况:

一区


链接:

https://academic.oup.com/nsr/article/doi/10.1093/nsr/nwx062/3888638/The-acidic-tumor-microenvironment-a-target-for



责任编辑:向丹婷



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