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刘庄教授课题组与彭睿教授课题组合作在ACS Nano上发表论文
发布时间:2018-09-18 点击:10

题目:

Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination


作者:

Rong Yang, Jun Xu, Ligeng Xu, * Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui   Peng,* and Zhuang Liu*


单位:

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for   Carbon-Based Functional Materials & Devices

摘要:

Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in the area of cancer immunotherapy in recent years. In this work, we present a strategy to construct cancer vaccines by encapsulating immune-adjuvant nanoparticles with cancer cell membranes modified by mannose. Poly(D,L-lactide-co-glycolide) nanoparticles are first loaded with toll-like receptor 7 agonist, imiquimod  (R837). Those adjuvant nanoparticles (NP-R) are then coated with cancer cell   membranes (NP-R@M), whose surface proteins could act as tumor-specific   antigens. With further modification with mannose moiety (NP-R@M-M), the   obtained nanovaccine shows enhanced uptake by antigen presenting cells such   as dendritic cells, which would then be stimulated to the maturation status to trigger antitumor immune responses. With great efficacy to delay tumor development as a prevention vaccine, vaccination with such NP-R@M-M in combination with checkpoint blockade therapy further demonstrates outstanding therapeutic efficacy to treat established tumors. Therefore, our work presents an innovative way to fabricate cancer nanovaccines, which in principle may be   applied for a wide range of tumor types.


影响因子:

13.709


分区情况:

一区


链接:

https://pubs.acs.org/doi/abs/10.1021/acsnano.7b09041


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