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刘庄教授课题组与汪超教授课题组合作在Advanced Functional Materials上发表综述
发布时间:2018-09-18 点击:21

题目:

Toward Biomaterials for Enhancing Immune Checkpoint Blockade

Therapy


作者:

Qin Fan1, Zhipeng Chen2, Chao Wang,*1 and Zhuang Liu*1


单位:

1Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu      Key Laboratory for Carbon-based Functional Materials and Devices,Soochow University, Suzhou, Jiangsu 215123, China

2Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Department of Pharmacy Nanjing University of Chinese  Medicine Nanjing 210023, China


摘要:

Despite the remarkable progress in immune checkpoint blockade (ICB)therapy for cancer treatment, low objective response and immune-relatedside effects (immune-related adverse events, irAEs) limit the further  development of ICBs. To address these challenges and enhance the efficiency of   cancer immunotherapy, the emerging interest has focused on manipulating biomaterials to form innovational drug delivery systems that are necessary to effectively deliver immune checkpoint inhibitors. Such biomaterial-based strategies can improve accumulation, control release, and enhance retentionof checkpoint inhibitors within target locations while simultaneously reducingdrug exposure for off-target tissues, thereby optimizing both the efficacy andsafety. In addition, with the assistance of biomaterials, combinations of ICBand conventional treatment strategies including chemotherapy, radiotherapy,and phototherapy are designed to further enhance the response rate of ICB.This review focuses on the latest reports on engineering biomaterials toimprove the antitumor efficiency of ICB, with stress on antibody-, gene-, and trapprotein–based immune checkpoint blockade strategies and their combinationswith conventional therapies. Challenges and future trends in engineeringbiomaterials tomodulate immune checkpoint therapy are discussed.


影响因子:

13.325


分区情况:

一区


链接:

https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201802540

                                                                                  


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