单位: | 1Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices,Soochow University, Suzhou, Jiangsu 215123, China 2Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Department of Pharmacy Nanjing University of Chinese Medicine Nanjing 210023, China
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摘要: | Despite the remarkable progress in immune checkpoint blockade (ICB)therapy for cancer treatment, low objective response and immune-relatedside effects (immune-related adverse events, irAEs) limit the further development of ICBs. To address these challenges and enhance the efficiency of cancer immunotherapy, the emerging interest has focused on manipulating biomaterials to form innovational drug delivery systems that are necessary to effectively deliver immune checkpoint inhibitors. Such biomaterial-based strategies can improve accumulation, control release, and enhance retentionof checkpoint inhibitors within target locations while simultaneously reducingdrug exposure for off-target tissues, thereby optimizing both the efficacy andsafety. In addition, with the assistance of biomaterials, combinations of ICBand conventional treatment strategies including chemotherapy, radiotherapy,and phototherapy are designed to further enhance the response rate of ICB.This review focuses on the latest reports on engineering biomaterials toimprove the antitumor efficiency of ICB, with stress on antibody-, gene-, and trapprotein–based immune checkpoint blockade strategies and their combinationswith conventional therapies. Challenges and future trends in engineeringbiomaterials tomodulate immune checkpoint therapy are discussed.
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