题目：

Highly Effective Radioisotope Cancer Therapywith a Non-Therapeutic Isotope Delivered andSensitized by Nanoscale CoordinationPolymers

作者：

Yu Chao, Chao Liang, Yu Yang, Guanglin Wang, Debabrata Maiti, Longlong Tian, Fei Wang, Wei Pan, Song Wu, *Kai Yang,* and Zhuang Liu*

单位：

^†Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials &Devices and

^‡State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & Schoolfor Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu HigherEducation Institutions, Soochow University, Suzhou, Jiangsu 215123, China

^§Institute of Urology of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen Luohu HospitalGroup, Shenzhen 518000, China

^∥College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

摘要：

Nuclear medicine with radioisotopes is extremelyuseful for clinical cancer diagnosis, prognosis, and treatment.Herein, polyethylene glycol (PEG)-modified nanoscale coordinationpolymers (NCPs) composed of hafnium (Hf⁴⁺) andtetrakis (4-carboxyphenyl) porphyrin (TCPP) are prepared via aone-pot reaction. By chelation with the porphyrin structure ofTCPP, such Hf-TCPP-PEG NCPs could be easily labeled with^99mTc⁴⁺, an imaging radioisotope widely used for single-photonemission computed tomography (SPECT) in a clinical environment.Interestingly, Hf, as a high-Z element in such ^99mTc-Hf-TCPP-PEG NCPs, could endow nontherapeutic 99mTc with thetherapeutic function of killing cancer cells, likely owing to theinteraction of Hf with γ rays emitted from ^99mTc to producecharged particles for radiosensitization. With efficient tumor retention, as revealed by SPECT imaging, our ^99mTc-Hf-TCPP-PEG NCPs offer exceptional therapeutic results in eliminating tumors with moderate doses of ^99mTc after eitherlocal or systemic administration. Importantly, those biodegradable NCPs could be rapidly excreted without much longtermbody retention. Our work, showing the success of applying NCPs for radioisotope therapy (RIT), presents apotential concept for the realization of highly effective cancer treatment with 99mTc, a short-half-life (6.0 h) diagnosticradioisotope, which is promising for cancer RIT with enhanced efficacy and reduced side effects.

影响因子：

13.709

分区情况：

一区

链接：

https://pubs.acs.org/doi/abs/10.1021/acsnano.8b02400