English 
     
   首 页
   热点信息
语言中心主任致辞
培养方案
专业介绍
招生问答
我院近期科研成果被国际学术...
联系我们
纳米科学技术学院2012年招生...
学生工作办公室简介
请加QQ群312279505
刘庄教授课题组在ACS Nano上发表论文
发布时间:2018-09-18 点击:10

题目:

Near-Infrared-Triggered in situ Gelation System for RepeatedlyEnhanced Photothermal-Brachytherapy with a Single Dose


作者:

Zhouqi Meng, Yu Chao, Xuanfang Zhou, Chao Liang, Jingjing Liu, Rui Zhang, LiangCheng, Kai Yang, Wei Pan#, Meifang Zhu§, Zhuang Liu,*


单位:

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory forCarbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu,215123, China.

& DevicesandState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection

& School of Radiation Medicineand Protection & School for Radiological and Interdisciplinary Sciences (RAD-X),Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher EducationInstitutions, Soochow University, Suzhou, Jiangsu 215123, China.

§ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China

 College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China


摘要:

Brachytherapy by placing therapeutic radioactive materials into or nearby tumors hasbeen widely used in the clinic for cancer treatment. The efficacy of brachytherapy, however,may often be limited by the radiation resistance for tumor cells located in the hypoxic regionof a solid tumor, as well as the non-optimal distribution of radioactivity inside the tumor.Herein, a hybrid hydrogel system is developed by using 131I-labeled copper sulfide (CuS/131I)nanoparticles as the photothermal-/radiotherapeutic agent, poly(ethylene glycol) doubleacrylates (PEGDA) as the polymeric matrix, and 2, 2’-azobis[2-(2-imidazolin-2-yl) propane]dihydrochloride (AIPH) as the thermal initiator, to realize light-induced in situ gelation in thetumor for the combined photothermal-brachytherapy. After local injection, CuS/131Inanoparticles under irradiation by the 915-nm near-infrared (NIR) laser would produce heat tomildly raise the tumor temperature and initiate the polymerization of PEGDA by activatingthe AIPH thermal initiator, effectively fixing CuS/131I by in situ gelation within the tumor forlong-term. By repeated NIR irradiation of tumors, the tumor hypoxia could be relieved for amuch longer term, resulting in a significant synergistic photothermal-brachytherapeutic effectto eliminate tumors. This work presents an efficient type of NIR-responsivenanoparticle-encapsulated hydrogel system, inspiring the design of the form of brachytherapy.


影响因子:

13.709


分区情况:

一区


链接:

https://pubs.acs.org/doi/abs/10.1021/acsnano.8b04544

                                                                                                                                   

                                                                                                                                        责任编辑:向丹婷


Copyright © 2012 苏州大学纳米科学技术学院 All Rights Reserved.
  地址:苏州工业园区仁爱路199号910楼  邮编:215123
您是第 位访问者