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刘庄教授课题组在Advanced Functional Materials上发表论文
发布时间:2018-09-18 点击:19

题目:

Covalent Organic Polymers Based on Fluorinated Porphyrin

as Oxygen Nanoshuttles for Tumor Hypoxia Reliefand Enhanced Photodynamic Therapy


作者:

Danlei Tao,1 Liangzhu Feng,*1 Yu Chao,1 Chao Liang,1 Xuejiao Song,1 Hairong Wang,1Kai Yang,2 and Zhuang Liu*1


单位:

1Institute of Functional Nano and Soft Materials (FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materialsand Devices, Soochow University, Suzhou 215123, China

2School of Radiation Medicine and Protection and School for Radiologicaland Interdisciplinary Sciences (RAD-X)Medical College of Soochow University, Suzhou 215123, China


摘要:

Effective and sustained tumor oxygenation has found practicalsignificance in benefiting the treatment of solid tumors. In this study,fluorinated covalent organic polymers (COPs) are prepared by crosslinkingthe photosensitizer meso-5, 10, 15, 20-tetra (4-hydroxylphenyl)porphyrin (THPP) with perfluorosebacic acid (PFSEA) and poly(ethyleneglycol) (PEG) via a one-pot esterification, to enable simultaneous tumoroxygenation and photodynamic treatment. Due to the presence of PFSEA,the obtained THPPpf–PEG shows efficient loading of perfluoro-15-crown-5-ether (PFCE), a type of perfluocarbon, and thereby molecular oxygen,both of which would significantly enhance the photodynamic effect ofTHPP. After chelating THPP with a radio-isotope, 99mTc, both THPPpf–PEG and PFCE-loaded THPPpf–PEG (PFCE@THPPpf–PEG) can be vividlyvisualized under the single-photon emission computed tomography(SPECT) imaging, which uncovers efficient tumor accumulation ofthose COPs’ post intravenous injection. Owing to the oxygen deliveryability of PFCE, efficient tumor oxygenation is observed for mice postinjection of PFCE@THPPpf–PEG, which further leads to greatly enhancedphotodynamic treatment of tumors. This study presents a unique typeof multifunctional fluorinated COPs with well-defined composition,long blood circulation time, and sustained tumor oxygenation ability,showing great promises for potential clinical translation in photodynamictreatment of tumors.


影响因子:

13.325


分区情况:

一区


链接:

https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201804901

                                                                 

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