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刘庄教授课题组在Nano Letters上发表论文
发布时间:2018-09-18 点击:10

题目:

Bimetallic Oxide MnMoOX Nanorods for in Vivo PhotoacousticImaging of GSH and Tumor-Specific Photothermal Therapy


作者:

Fei Gong, Liang Cheng,*, Nailin Yang, Qiutong Jin, Longlong Tian, Mengyun Wang,Yonggang Li, and Zhuang Liu*,


单位:

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials andDevices, Soochow University, Suzhou 215123, China

Department of Radiology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China


摘要:

Accurate imaging of glutathione (GSH) in vivois able to provide real-time visualization of physiological andpathological conditions. Herein, we successfully synthesizebimetallic oxide MnMoOX nanorods as an intelligent nanoprobefor in vivo GSH detection via photoacoustic (PA) imaging.The obtained MnMoOX nanoprobe with no near-infrared(NIR) absorption in the absence of GSH would exhibit strongGSH-responsive NIR absorbance, endowing PA imagingdetection of GSH. Due to the up-regulated GSH concentrationin the tumor microenvironment, our MnMoOX nanoprobecould be utilized for in vivo tumor-specific PA imaging.Moreover, MnMoOX nanorods with GSH-responsive NIRabsorbance could also be employed to achieve tumor-specificphotothermal therapy (PTT). Importantly, such MnMoOX nanorods show inherent biodegradability and could be rapidlycleared out from the body, minimizing their long-term body retention and potential toxicity. Our work presents a new type of GSH-responsive nanoprobe based on bimetallic oxide nanostructures, promising for tumor-specific imaging and therapy



影响因子:

12.080


分区情况:

一区


链接:

https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.8b02933



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