冯良珠

教授，博士生导师

       2010年于苏州大学基础医学与生命科学学院获理学学士学位；2015年于苏州大学功能纳米与软物质研究院获理学博士学位，期间获“国家留学基金委公派研究生项目”资助，于2013年9月—2014年10月赴美国佐治亚理工学院生物工程系访学；2015年10月—2016年10月于澳门大学中华医药研究院从事博士后研究。2016年11月加入苏州大学功能纳米与软物质研究院任助理研究员；2018年7月晋升为副研究员，同年入选“苏州大学优秀青年学者”；2022年7月晋升为研究员；2023年转聘为特聘教授，博士生导师。

研究领域：

1. 仿生纳米载体与肿瘤靶向药物递送

2. 生物催化材料与肿瘤生物催化治疗

3. 金属离子载体与肿瘤离子干扰治疗

4. 肿瘤微环境调控与序贯性联合治疗

主要学术成果：        

       冯良珠教授在功能化生物材料的设计构建与增效肿瘤治疗方面开展创新研究。先后发展了一系列新型碳酸钙基微纳载体用于肿瘤微酸响应性药物控释与免疫抑制性微环境调控；构建了多种离子型水凝胶用于提升肝癌消融治疗的精准性与免疫原性；设计了多种仿生矿化肿瘤疫苗用于预防术后肿瘤复发与转移这一临床难题。迄今在Science Advances, Nature Communications, Chem, J. Am. Chem. Soc., Adv. Mater., Natl. Sci. Rev., Chem. Rev.等高水平学术期刊上发表第一/通讯作者论文60余篇，文章的总他引18200余次，SCI H-index为61；四次入选了美国美国科睿唯安公布的“全球高被引科学家名单”（Highly Cited Researchers，交叉领域，2019、2021-2023年）；受邀担任了Materials Today Bio, Exploration, BMEMater等多个学术期刊的青年编委；主持/参与了国自然优秀青年基金、科技部重点研发计划、江苏省优秀青年基金等9项省部级科研项目资助。

荣誉奖励：

2023   国自然优秀青年基金

2023   科睿唯安-全球高被引科学家（交叉学科）

2022   科睿唯安-全球高被引科学家（交叉学科）

2022   江苏省优秀青年基金

2021   科睿唯安-全球高被引科学家（交叉学科）

2019   科睿唯安-全球高被引科学家（交叉学科）

2016   江苏省科学技术一等奖 （排名第五）

学术兼职：

Young Editorial Board Members, Exploration (2023-)

Young Editorial Board Members, BMEMat (2022-)

ECR board member, Materials Today Bio (IF = 10.761, Q1, 2022-)

招生方向：

本课题组热忱欢迎有志从事科研工作的本科生、硕士研究生、博士研究生以及交流生到课题组学习工作。招生方向包括化学、材料学、生物化学与分子生物学、免疫学和生物医学工程等。有疑问请随时邮件联系lzfeng@suda.edu.cn。

招聘信息：

根据课题组发展需要，现拟招聘1-2名从事高分子合成、医学免疫学、生物医学工程等相关研究方向的博士后研究人员，待遇优厚。有意者请发送简历至 lzfeng@suda.edu.cn。

代表性论文：

[24] Ziliang Dong, Lei Zhang, Dongxu Zhao, Chunjie Wang, Yu Hao, Quguang Li, Yunyun Zhang, Zhijuan Yang, Caifang Ni*, Zhuang Liu*, Liangzhu Feng*, Procoagulant CaCO₃-embedded embolic microspheres can potentiate transcatheter arterial embolization of hepatocellular carcinoma. Nano Today, 2024, 55, 102216.

[23] Yan Liu*, Yu Hao, Jiahui Chen, Minming Chen, Jia Tian, Xiang Lv, Yefei Zhang, Xinxing Ma, Yehui Zhou, and Liangzhu Feng*, An Injectable Puerarin Depot Can Potentiate Chimeric Antigen Receptor Natural Killer Cell Immunotherapy Against Targeted Solid Tumors by Reversing Tumor Immunosuppression. Small, 2024, 2307521.

[22] Ziliang Dong, Yan Liu, Chunjie Wang, Yu Hao, Qin Fan, Zhijuan Yang, Quguang Li, Liangzhu Feng*, Zhuang Liu*, Tumor Microenvironment Modulating CaCO3-Based Colloidosomal Microreactors Can Generally Reinforce Cancer Immunotherapy. Adv. Mater., 2023, 2308254.

[21] Yan Liu*, Yu Hao, Xiang Lv, Yefei Zhang, Jiahui Chen, Jia Tian, Xinxing Ma, Yehui Zhou, Liangzhu Feng*, A Tetramethylpyrazine Releasing Hydrogel can Potentiate CAR-T Cell Therapy against Triple Negative Breast Cancer by Reprogramming Tumor Vasculatures. Fundam. Res., 2023, doi.org/10.1016/j.fmre.2023.05.016.

[20] Chunjie Wang, Lei Zhang, Zhijuan Yang, Dongxu Zhao, Zheng Deng, Jialu Xu, Yumin Wu, Yu Hao, Ziliang Dong, Liangzhu Feng*, Zhuang Liu*, Self-fueling ferroptosis-inducing microreactors based on pH-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy. Natl. Sci. Rew., 2023, 11, nwad257.

[19] Quguang Li, Ziliang Dong, Zhiqin Cao, Huali Lei, Chunjie Wang, Yu Hao, Liangzhu Feng,* Zhuang Liu*, A General Biomineralization Strategy to Synthesize Autologous Cancer Vaccines with cGAS-STING Activating Capacity for Postsurgical Immunotherapy. ACS Nano, 2023, 17, 10496-0510.

[18] Yujie Zhu, Zhijuan Yang, Zijian Pan, Yu Hao, Chunjie Wang, Ziliang Dong, Quguang Li, Yikai Han, Longlong Tian, Liangzhu Feng*, Zhuang Liu*, Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment. Sci. Adv., 2022, 8(31), abo5285.

[17] Yu Hao, Lei Zhang, Ziliang Dong, Chunjie Wang, Yu Chao, Dongxu Zhao, Yujie Zhu, Zhijuan Yang, Nailin Yang, Yikai Han, Liangzhu Feng*, Zhuang Liu*, Percutaneous implantation of ethanol fueled catalytic hydrogel suppresses tumor growth by triggering ferroptosis. Mater. Today, 2022, 55, 7-20.

[16] Zhijuan Yang, Yujie Zhu, Ziliang Dong, Yu Hao, Chunjie Wang, Quguang Li, Yumin Wu, Liangzhu Feng*, Zhuang Liu*, Engineering bioluminescent bacteria to boost photodynamic therapy and systemic anti-tumor immunity for synergistic cancer treatment. Biomaterials, 2022, 281, 121332.

[15] Chunjie Wang, Ziliang Dong, Yu Hao, Yujie Zhu, Jing Ni, Quguang Li, Bo Liu, Yikai Han, Zhijuan Yang, Jianmei Wan, Kai Yang, Zhuang Liu*, Liangzhu Feng*, Coordination Polymer-Coated CaCO₃ Reinforces Radiotherapy by Reprogramming the Immunosuppressive Metabolic Microenvironment. Adv. Mater., 2022, 34(3), 2106520.

[14] Zhijuan Yang, Yujie Zhu, Ziliang Dong, Wei Li, Nailin Yang, Xianwen Wang, Liangzhu Feng*, Zhuang Liu*, Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses. Nat. Commun., 2021, 12, 4299.

[13] Yujie Zhu, Zhijuan Yang, Ziliang Dong, Yimou Gong, Yu Hao, Longlong Tian, Xianzhu Yang, Zhuang Liu*, Liangzhu Feng*, CaCO₃-Assisted Preparation of pH-Responsive Immune-Modulating Nanoparticles for Augmented Chemo-Immunotherapy. Nano-Micro Lett., 2021, 13(1),1-18.

[12] Ziliang Dong, Liangzhu Feng*, Yu Hao, Quguang Li, Muchao Chen, Zhijuan Yang, He Zhao, Zhuang Liu*, Synthesis of CaCO₃-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress. Chem, 2020, 6(6), 1391-1407.

[11] Ziliang Dong, Liangzhu Feng*, Yu Chao, Yu Hao, Muchao Chen, Fei Gong, Xiao Han, Rui Zhang, Liang Cheng, Zhuang Liu*, Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy. Nano Lett., 2019, 19, 805-815.

[10] Ziliang Dong, Liangzhu Feng*, Yu Hao, Muchao Chen, Min Gao, Yu Chao, He Zhao, Wenwen Zhu, Jingjing Liu, Chao Liang, Qiao Zhang, and Zhuang Liu*, Synthesis of Hollow Biomineralized CaCO₃-Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity. J. Am. Chem. Soc., 2018, 140, 2165–2178.

[9] Danlei Tao, Liangzhu Feng*, Yu Chao, Chao Liang, Xuejiao Song, Hairong Wang, Kai Yang, Zhuang Liu*, Covalent Organic Polymers Based on Fluorinated Porphyrin as Oxygen Nano-Shuttles for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy. Adv. Funct. Mater. 2018, 28, 1804901.

[8]Liangzhu Feng*, Ziliang Dong*,, Chao Liang, Muchao Chen, Danlei Tao, Liang Cheng, Kai Yang, Zhuang Liu*, Iridium Nanocrystals Encapsulated Liposomes as Near-Infrared Light Controllable Nanozymes for Enhanced Cancer Radiotherapy. Biomaterials, 2018, 181, 81-91. 

[7] Yicheng Zhang, Liangzhu Feng*, Jun Wang, Danlei Tao, Chao Liang, Liang Cheng, Erhong Hao*, Zhuang Liu*, Surfactant‐Stripped Micelles of Near Infrared Dye and Paclitaxel for Photoacoustic Imaging Guided Photothermal‐Chemotherapy. Small, 2018, 14, 1802991.  

[6] Liangzhu Feng, Ziliang Dong, Danlei Tao, Yicheng Zhang, Zhuang Liu*, The acidic tumor microenvironment: a target for smart cancer nano-theranostics. Natl. Sci. Rev., 2018, 5, 269-286.

[5] Liangzhu Feng, Danlei Tao, Ziliang Dong, Qian Chen, Yu Chao, Zhuang Liu*, Meiwan Chen*, Near-infrared Light Activation of Quenched Liposomal Ce6 for Synergistic Cancer Phototherapy with Effective Skin Protection. Biomaterials, 2017, 127, 13-24.

[4] Liangzhu Feng, Min Gao, Danlei Tao, Qian Chen, Hairong Wang, Ziliang Dong, Meiwan Chen,* and Zhuang Liu*, Cisplatin-Prodrug-Constructed Liposomes as a Versatile Theranostic Nanoplatform for Bimodal Imaging Guided Combination Cancer Therapy. Adv. Funct. Mater., 2016, 26, 2207-2217.

[3] Ziliang Dong, Liangzhu Feng*, Wenwen Zhu, Xiaoqi Sun, Min Gao, He Zhao, Yu Chao, Zhuang Liu*, CaCO₃ Nanoparticles as an Ultra-sensitive Tumor-pH-Responsive Nanoplatform Enabling Real-Time Drug Release Monitoring and Cancer Combination Therapy. Biomaterials, 2016, 110, 60-70.

[2] Liangzhu Feng*, Xianzhu Yang*, Xiaoze Shi, Xiaofang Tan, Rui Peng, Jun Wang*, Zhuang Liu*, Polyethylene glycol and polyethylenimine dual functionalized nano-graphene oxide for photothermally enhanced gene delivery. Small, 2013, 9 (11), 1989-1997.

[1] Liangzhu Feng, Shuai Zhang, Zhuang Liu*, Graphene based gene transfection, Nanoscale, 2011, 3 (3), 1252-1257.

发表论文 列表：

https://scholar.google.com/citations?user=MkQwgDsAAAAJ&hl=en

联系方式：

办公室：910-208B

电话：0512-65883996

E-mail: lzfeng@suda.edu.cn