高分子材料与仿生载体


方向介绍  

 高分子材料与仿生载体是本实验室的一个重要研究方向。本实验室发展了多种基于可降解高分子、共轭有机高分子、有机金属框架(MOF)与配位高分子(Coordination Polymer)、生物大分子(如蛋白)、红细胞和细胞膜包覆仿生材料的智能载体。基于这类材料优异的生物安全性,以及其独特的物理、化学与生理功能,我们探索其在光声成像、药物输送、肿瘤光学治疗、肿瘤微环境调控和肿瘤免疫治疗等方面的应用。


主要研究方向  

- 高分子纳米探针与光声成像;
- 智能纳米药物载体与肿瘤创新疗法;
- 多功能仿生材料的开发与应用;
- 高分子水凝胶在肿瘤治疗、组织损伤修复和组织工程方面的应用。


代表性论文

[10] Qian Chen, Chao Liang, Xiaoqi Sun, Jiawen Chen, Zhijuan Yang, He Zhao, Liangzhu Feng, Zhuang Liu*. “H2O2-responsive Liposomal Nanoprobe for Photoacoustic Inflammation Imaging and Tumor Theranostics via In Vivo Chromogenic Assay” Proc. Natl. Acad. Sci. U.S.A., 114(21), 5343-5348 (2017).
[9] Yu Yang, Wenjun Zhu, Ziliang Dong, Yu Chao, Lai Xu*, Meiwan Chen*, Zhuang Liu*. “1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy” Adv. Mater., 29(40), 1703588 (2017).
[8] Min Gao, Chao Liang, Xuejiao Song, Qian Chen, Qiutong Jin, Chao Wang, Zhuang Liu*. “Erythrocyte Membrane-Enveloped Perfluorocarbon as Nanoscale Artificial Red Blood Cells to Relieve Tumor Hypoxia and Enhance Cancer Radiotherapy” Adv. Mater., 29(35), 1701429 (2017)
[7] Qian Chen, Ligeng Xu, ChaoLiang, Chao Wang, Rui Peng, and Zhuang Liu*. “Photothermal Therapy with Immune-adjuvant Nanoparticles Together with Checkpoint Blockade for Effective Cancer Immunotherapy” Nat. Commun., 7, 13193 (2016)
[6] Qian Chen, Liangzhu Feng, Jingjing Liu, Wenwen Zhu, Ziliang Dong, Yifan Wu, Zhuang Liu*. “Intelligent Albumin–MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy” Adv. Mater., 28,7129-7136 (2016)
[5] Qian Chen, Zhuang Liu*. “Albumin Carriers for Cancer Theranostics: A Conventional Platform with New Promises” Adv. Mater., 28, 10557-10566 (2016)
[4] Qian Chen, Xiaodong Liu, Jiawen Chen, Jianfeng Zeng*, Zhenping Cheng, Zhuang Liu*. “A Self-assembled Albumin-based Nanoprobe for in vivo Ratiometric Photoacoustic pH Imaging” Adv. Mater. 27, 6820–6827 (2015)
[3] Xiaoqi Sun, Chao Wang, Min Gao, Aiyan Hu, and Zhuang Liu*. “Remotely Controlled red Blood Cell Carriers for Cancer Targeting and Near-infrared Light-triggered Drug Release in Combined Photothermal-Chemotherapy” Adv. Funct. Mater., 25, 2386-2394 (2015)
[2] Qian Chen, Chao Liang, Chao Wang, Zhuang Liu*. “An Imagable and Photothermal “Abraxane-Like” Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors” Adv. Mater., 27, 903-910, (2015)
[1] Chao Wang, Xiaoqi Sun, Liang Cheng, Shengnan Yin, Guangbao Yang, Yonggang Li, Zhuang Liu*. “Multifunctional Theranostic Red Blood Cells for Magnetic Field Enhanced in vivo Combination Therapy of Cancer” Adv. Mater., 26, 4794-4802 (2014)

  

  

  


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