我组黄慧在ACS Applied Bio Materials上发表论文

题目：

Photocatalytic Polymerization from Amino Acid to Protein byCarbon Dots at Room Temperature

作者：

Hui Huang,†,∥ Siwei Yang,‡,∥ Yang Liu,*,† Yucheng Yang,‡ Hao Li,† John A. McLeod,†Guqiao Ding,*,‡ Jian Huang,†,§ and Zhenhui Kang*,†

单位：

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials andDevices and §School of Biology & Basic Medical Science, Soochow University, Suzhou 215123, China

‡State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology,Chinese Academy of Sciences, Shanghai 200050, China

摘要：

The chemical origins of life have been widely accepted at the present stage.

However, the idea that amino acids further react to produce peptides and proteins remainsan unsatisfactory explanation, because producing polypeptides via spontaneous reaction ofamino acids in solution is extremely difficult. It is also necessary to further answer whetheramino acids can form longer peptide chains as well as specific chiral structures and so onunder this same reaction mechani**. Carbon dots (CDs) have been intensively researchedover the past years due to their unique chemical and physical properties. Here, wedemonstrate the photocatalytic polymerization of amino acids into polypeptides andproteins using CDs as a photocatalyst, in which the synthetic conditions required are onlyroom temperature (or as low as −20 °C) and aqueous conditions along with light

irradiation, which are very mild and easy to satisfy. We even obtain a protein with tertiarystructures, namely an artificial insulin with the biological function to reduce the blood sugarof the laboratory mice. The innovation of using CDs to initiate amino acids to condenseinto polypeptides is based on strong adsorption (e.g., hydrogen bonding), the acidity of the −OH surface functional groups, andthe photogenerated protons/holes, which are the fundamental factors for polypeptide or even ternary structure proteinformation by means of capturing and condensing the amino acids as well as forming the S−S bonds.

影响因子：

4.47

分区情况：

链接：  

 https://pubs.acs.org/doi/pdf/10.1021/acsabm.9b008