Chenglong Ge

Research Associate Professor

Education and Professional Experiences

2024.10-Present: Research Associate Professor, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University

2021.07-2024.06: Postdoctoral fellow, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University

2018.09-2021.06: Ph.D., Chemistry, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University

2015.09-2018.06: Master's degree, Chemistry, The College of Chemistry, Xiangtan University

2011.09-2015.06: Bachelor's degree, Polymer Materials and Engineering, The College of Chemistry, Xiangtan University

Funding

1.  NSFC Youth Science Foundation

2.  Natural Science Foundation of Jiangsu Province for Youth Program

3.  China Postdoctoral Science Foundation

Research Interests

Ge's research mainly focuses on 1) controllable ring-opening polymerization and methodology of synthetic polypeptides, 2) secondary structure regulation and biological effect of polypeptides, and 3) the construction of polymer carriers for trans-barrier delivery of genes, drugs, and proteins. He has published over 12 papers (first/corresponding author): including J Am Chem Soc、Nano Lett、Chin J Chem、Biomacromolecules、J Mater Chem B.

Publications

1. Fan Zhang^#, Chenglong Ge^#, Zigang Qiao, Yu Han, Lichen Yin*, Feng Ma*. Protocol for siRNA-mediated U1 snRNA Knockdown using Fluorinated α-Helical Polypeptide In vitro and In vivo. STAR Protocols, 2024, 5, 103238.

2. Chenglong Ge^#, Jianyin He^#, Mudan, Gan^#, Yu Qian, Junliang Zhu, Fan Wu, Ziyuan Song*, Lichen Yin*. Conformation-Switchable Polypeptides as Molecular Gates for Controllable Drug Release. Biomacromolecules, 2024, 25, 3373-3383.

3. Chenglong Ge, Junliang Zhu, Huan Ye, Yuansong Wei, Yuheng Lei, Renxiang Zhou, Ziyuan Song, Lichen Yin*. Rational Construction of Protein-mimetic Nano-switch System Based on Secondary Structure Transition of Synthetic Polypeptide. J Am Chem Soc, 2023, 145, 11206-11214.

4. Junliang Zhu^#, Yunjie He^#, Chenglong Ge*, Wenting Si, Ziyuan Song*, Lichen Yin*. Accelerated Ring-opening Polymerization of α-Amino Acid N-carboxyanhydride via Inorganic Nano-initiators. Chin J Chem, 2023, 41, 2476-2482.

5. Chenglong Ge^#, Junliang Zhu^#, Guangqi Wu, Huan Ye, Hua Lu*, Lichen Yin*. ROS-Responsive Selenopolypeptide Micelles: Preparation, Characterization, and Controlled Drug Release. Biomacromolecules, 2022, 23, 2647-2654.

6. Chenglong Ge, Yong Liu, Lichen Yin*. Effect and Regulation of the Secondary Structure of Synthetic Poly(α-amino acid) based on Ring-opening Polymerization. Chin Sci Bull, 2021, 66, 2217-2230.

7. Chenglong Ge, Huan Ye, Fan Wu, Junliang Zhu, Ziyuan Song, Yong Liu,* Lichen Yin*. Biological Applications of Water-Soluble Polypeptides with Ordered Secondary Structures. J Mater Chem B, 2020, 8, 6530-6547.

8. Chenglong Ge^#, Jiandong Yang^#, Shanzhou Duan, Yong Liu, Fenghua Meng, Lichen Yin*. Fluorinated α-Helical Polypeptides Synchronize Mucus Permeation and Cell Penetration Toward Highly Efficient Pulmonary siRNA Delivery Against Acute Lung Injury. Nano Lett, 2020, 20, 1738-1746.

9. Chenglong Ge, Ying Ling*, Shunjie Yan, Shifang Luan, Haowen Zhang, Haoyu Tang*. Preparation and Mechanical Properties of Strong and Tough Poly(vinyl alcohol)-Polypeptide Double-Network Hydrogels. Eur Polym J, 2018, 99, 504-510.

10. Chenglong Ge, Wenjun Liu, Ying Ling*, Haoyu Tang*. Synthesis and Thermoresponsive Properties of OEGylated Polypeptide with a LCST at Body Temperature in Water and with a UCST in Alcohol or Ethanol/Water Solvent Mixture. J Polym Sci, Part A: Polym Chem, 2018, 56, 163-173.

11. Chenglong Ge, Liang Zhao, Ying Ling*, Haoyu Tang*. Thermo and pH Dual Responsive Polypeptides Derived from “Clickable” Poly(γ-3-methylthiopropyl-_L-glutamate). Polym Chem, 2017, 8, 1895-1905.

12. Chenglong Ge, Sheng Liu, Ce Liang, Ying Ling*, Haoyu Tang*. Synthesis and UCST-type Phase Behavior of α-Helical Polypeptides with Y-shaped and Imidazolium Pendants. Polym Chem, 2016, 7, 5978-5987.

 Book

1. Chenglong Ge, Xun Liu, Lichen Yin. Gene Delivery (chapter 4), in “Biomaterial Engineering, Fluorinated α-Helical Polypeptides Toward Pulmonary siRNA Delivery”. Springer Nature, edited by Youqing Shen, Huayu Tian, Xuesi Chen. pp 75-96.

Edited by Juan Yang