Yang Zhou

Associate Professor

Education and Professional Experiences

2025/9-Present: Associate Professor, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University

2023/01-2025/06: Postdoctoral Fellow, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University

2022/07-2022/12: Visiting Scholar, Westlake University, Advisor: Prof. Jianjun Cheng

2017/09-2022/06: Ph.D., Chemistry, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University

2013/09-2017/06: B. E., Nano Materials and Technology, College of Nano Science & Technology (CNST), Soochow University

Email

yangzhou@suda.edu.cn

Awards

2025 Soochow University’s Outstanding Young Scholar

2024 Wiley China Excellent Author Program

2023 Jiangsu Excellent Postdoctoral Project

Funding

1. NSFC Youth Science Foundation

2. China Postdoctoral Science Foundation

Research Interests

1. Inflammatory mediator-scavenging systems based on biomimetic nanomaterials

2. Immunomodulatory nanosystems based on conformation-switchable polypeptides

3. Gene/drug delivery systems capable of penetrating physiological barriers

Publications

1. Yang Zhou^#, Huan Ye^#, Yi Yu, Chenglong Ge, Mengyuan Yin, Zhongmin Liu, Jingrui Shen, Renxiang Zhou, Youyong Li*, Kam W. Leong*, Lichen Yin*. Helix-guarded molecular clips for cell-free DNA scavenging and treatment of systemic lupus erythematosus. J. Am. Chem. Soc. 2025, 147, 6612-6622.

2. Yang Zhou, Zhiyong Liu, Mengyuan Yin, Chenglong Ge, Zhongmin Liu, Renxiang Zhou, Duanmin Hu*, Lichen Yin*. Multi-target nanoscavengers for interrupting the feed-forward inflammatory cycle in autoimmune diseases. Adv. Funct. Mater. 2025, in press.

3. Wenhan Zhao^#, Yang Zhou^#, Lichen Yin*. Cell-free DNA-scavenging nano/microsystems for immunotherapy. J. Control. Release 2025, 381, 113609.

4. Jingrui Shen, Yang Zhou*, Lichen Yin*. Nano/genetically engineered cells for immunotherapy. BMEMat 2025, 3, e12112.

5. Fuwei Qi^#, Yinsheng Liao^#, Chenglong Ge, Yiyao Yang, Junliang Zhu, Jiang Zhu*, Yang Zhou*, Hong Xie*, Lichen Yin*. Intranasally delivered echinacoside micelles modulate mitochondrial fusion against postoperative cognitive dysfunction. Adv. Funct. Mater. 2025, DOI: 10.1002/adfm.202505499.

6. Zhongmin Liu, Jing Yan, Yang Zhou*, Mengyuan Yin, Renxiang Zhou, Jingrui Shen, Duanmin Hu*, Lichen Yin*. Biomimetic immunoregulators for the multi-target inflammation interruption in autoimmune disease. ACS Nano 2025, 19, 27294-27309.

7. Mengyuan Yin^#, Chenglong Ge^#, Yang Zhou^#, Renxiang Zhou, Yiyao Yang, Yu Qian, Jianyin He, Jingrui Shen, Lichen Yin*. Inflammation-activatable nanoscavengers for sustainable cell-free DNA capture and cleavage. Adv. Mater. 2025, DOI: 10.1002/adma.202504557.

8. Renxiang Zhou^#, Yang Zhou^#, Mengyuan Yin, Chenglong Ge, Yiyao Yang, Jingrui Shen, Lichen Yin*. Inflammation-responsive polyion complex vesicles for autoimmune disease therapy via cell-free DNA scavenging and inflammatory microenvironment modulation. ACS Nano 2024, 18, 30017-30030.

9. Qinghua Wu^#, Yang Zhou^#, Jing Yan, Xudong Li, Fenghua Meng*, Bin Wang*, Lichen Yin*. Biomimetic nanocomplexes orchestrate post-stroke cerebral microenvironment via microglia-targeted siRNA delivery. Nano Today 2024, 58, 102444.

10. Mengyuan Yin, Zhongmin Liu, Yang Zhou*, Wei Li, Jing Yan, Desheng Cao, Lichen Yin*. Two-pronged anti-cancer nanovaccines enpowered by exogenous/ endogenous tumor-associated antigens. J. Control. Release 2024, 373, 358-369.

11. Wenxin Zhang^#, Jingrui Shen^#, Jialong Liang, Chenglong Ge, Yang Zhou*, Lichen Yin*, Yong Ji*. Pulmonary RNA interference against acute lung injury mediated by mucus- and cell-penetrating nanocomplexes. Acta Biomater. 2024, 177, 332-346.

12. Bingchen Shan^#, Yang Zhou^#, Mengyuan Yin, Yekun Deng, Chenglong Ge, Zhongmin Liu, Renxiang Zhou, Qirong Dong*, Xiaozhong Zhou*, Lichen Yin*. Macrophage membrane-reversibly cloaked nanotherapeutics for the anti-inflammatory and antioxidant treatment of rheumatoid arthritis. Small Methods 2023, 7, 2300667.

13. Jianhui Lu^#, Jiaheng Zhang^#, Wen Yan, Chenglong Ge, Yang Zhou*, Rongying Zhu, Shanzhou Duan, Lichen Yin*, Yongbing Chen*. MicroRNA-208a silencing against myocardial ischemia/reperfusion injury mediated by reversibly camouflaged biomimetic nanocomplexes. Nano Res. 2023, 16, 11176-11185.

14. Yang Zhou^#, Qiujun Liang^#, Xuejie Wu, Shanzhou Duan, Chenglong Ge, Huan Ye, Jianhui Lu, Rongying Zhu, Yongbing Chen, Fenghua Meng, Lichen Yin*. siRNA delivery against myocardial ischemia reperfusion injury mediated by reversibly camouflaged biomimetic nanocomplexes. Adv. Mater. 2023, 35, 2210691.

15. Yang Zhou^#, Yekun Deng^#, Zhongmin Liu, Mengyuan Yin, Mengying Hou, Ziyin Zhao, Xiaozhong Zhou, Lichen Yin*. Cytokine-scavenging nanodecoys reconstruct osteoclast/osteoblast balance toward the treatment of postmenopausal osteoporosis. Sci. Adv. 2021, 7, eabl6432.

16. Yekun Deng^#, Yang Zhou^#, Qiujun Liang, Chenglong Ge, Jiandong Yang, Bingchen Shan, Yong Liu, Xiaozhong Zhou*, Lichen Yin*. Inflammation-instructed hierarchical delivery of IL-4/miR-21 orchestrates osteoimmune microenvironment toward the treatment of rheumatoid arthritis. Adv. Funct. Mater. 2021, 31, 2101033.

17. Huan Ye^#, Yang Zhou^#, Xun Liu, Yongbing Chen*, Shanzhou Duan, Rongying Zhu, Yong Liu*, Lichen Yin*. Recent advances on reactive oxygen species-responsive delivery and diagnosis system. Biomacromolecules 2019, 20, 2441-2463.

18. Yang Zhou^#, Huan Ye^#, Yongbing Chen, Rongying Zhu, Lichen Yin*. Photoresponsive drug/gene delivery systems. Biomacromolecules 2018, 19, 1840-1857.

19. Wenxin Zhang^#, Yang Zhou^#, Xudong Li, Xin Xu, Yongbing Chen*, Rongying Zhu, Lichen Yin*. Macrophage-targeting and reactive oxygen species (ROS)-responsive nanopolyplexes mediate anti-inflammatory siRNA delivery against acute liver failure (ALF). Biomater. Sci. 2018, 6, 1986-1993.

Edited by Juan Yang