Yu Chao
Associate Professor, master's supervisor
In 2015, he received a bachelor's degree in Biological Functional Materials from Soochow University. Doctor degree in Chemistry from Soochow University in 2020; From 2020 to 2023, he worked as a postdoctoral researcher at Soochow University. In 2023, he joined the Institute of Functional Nano and Soft Matter of Soochow University and was hired as an associate professor.
Major achievements and technical contributions：
In recent years, he has been actively involved in research in the field of nano-biomaterials and tumor immunotherapy. He has successfully developed a series of drug delivery systems based on natural polymer materials and systematically explored novel strategies for localized tumor therapy using biological materials and mediated tumor immunotherapy. Furthermore, significant progress has been made in the construction of natural polymer hydrogel carriers, loading and release mechanisms for small or large molecule drugs, regulation of the tumor microenvironment, as well as enhancement of biomaterial immune checkpoint blocking therapy. These research findings have garnered substantial international recognition. The clinical translation of these technologies is steadily advancing with completion of initial human administration trials.
He has published 70 SCI papers in international academic journals, including Nature Reviews Bioengineering and Nature Biomedical Engineering as the first author or co-author. Additionally, he has contributed to Science Advances and Advanced Functional Materials with his publications. Furthermore, he has made significant contributions to internationally renowned academic journals such as Materials, Nano Letters, ACS Nano, Biomaterials, and Small by publishing 10 papers. Many of these articles have received frequent citations and extensive coverage from the National Natural Science Foundation and related academic media outlets. The cumulative citation count for his work exceeds 7,000 times with an H-index of 44. Moreover, he has successfully filed five invention patents which have all been transferred.
Awards：
In 2020, won the May 4th Youth title of Soochow University;
In 2020, it won the China Postdoctoral Innovative Talent Support Program
Enrollment direction:
The research direction warmly welcomes the undergraduates and postgraduates who are interested in scientific research to study and work in the research group. The admission direction is Materials Science and Engineering (04 direction, biomanomaterials and biomedical materials). Students with a background in chemistry, materials or biomedicine are welcome to apply. Please feel free to contact us by email: ychao@suda.edu.cn, if you have any questions
Publish paper
http://www.researcherid.com/rid/K-9840-2015
https://scholar.google.com/citations?user=qXNS1XUAAAAJ&hl=zh-CN
Representative paper：
[1] Yu Chao, Zhuang Liu*,“Biomaterials tools to modulate the tumour microenvironment in immunotherapy”, Nature Reviews Bioengineering, 1, 125-138 (2023).
[2] Zhu, Wenjun┼; Chao, Yu┼; Jin, qiutong; Chen, Linfu; Shen, Jing-Jing; Zhu, Jiafei; Chai, Yu; Lu, Panhao; Yang, Nailin ; Chen, Muchao; Yang, Yang; Chen, Qian; Liu, Zhuang*, “Oral delivery of therapeutic antibodies with a transmucosal polymeric carrier”, ACS Nano, 10.1021/acsnano.2c09266 (2023). (┼ equal contribution authors)
[3] Yu Chao, Ting Wei, Qiaofeng Li, Bo Liu, Yu Hao, Muchao Chen, Yuzhe Wu, Fanxin Song, Qian Chen*, Zhuang Liu*, Metformin-containing Hydrogel Scaffold to Augment CAR-T Therapy Against Post-surgical Solid Tumors, Biomaterials, 10.1016/j.biomaterials.2023.122052 (2023).
[4] Qiaofeng Li, Yu Chao*, Bo Liu, Zhisheng Xiao, Zhijuan Yang, Yuzhe Wu, Zhuang Liu*, “Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy”, Biomaterials, 291,121880 (2022).
[5] Yu Chao, Chao Liang, Huiquan Tao, Yaran Du, Di Wu, Ziliang Dong, Qiutong Jin, Guobin Chen, Jun Xu, Zhisheng Xiao, Qian Chen, Chao Wang, Jian Chen, Zhuang Liu*. “Localized cock-tail chemo-immunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.” Science Advances, 6(10), eaaz4204 (2020)
[6] Yu Chao, Guobin Chen, Chao Liang, Jun Xu, Ziliang Dong, Xiao Han, Chao Wang, Zhuang Liu*. “Iron Nanoparticles for Low-Power Local Magnetic Hyperthermia in Combination with Immune Checkpoint Blockade for Systemic” Nano Lett., 19(7), 4287- 4296 (2019)
[7] Yu Chao, Qian Chen*, Zhuang Liu*. “Smart Injectable Hydrogels for Cancer Immunotherapy” Adv. Funct. Mater.,1902785 (2019)
[8] Yu Chao, Ligeng Xu, Chao Liang, Liangzhu Feng, Jun Xu, Ziliang Dong, Longlong Tian, Xuan Yi, Kai Yang*, Zhuang Liu*. Combined Local Immunostimulatory Radioisotope Therapy and Systemic Immune Checkpoint Blockade Imparts Potent Antitumour Responses Nature Biomedical Engineering, 2, 611-621(2018)
[9] Yu Chao, Chao Liang, Yu Yang, Guanglin Wang, Debabrata Maiti, Longlong Tian, Fei Wang, Wei Pan, Song Wu*, Kai Yang*, Zhuang Liu*. Highly Effective Radioisotope Cancer Therapy with a Non-Therapeutic Isotope Delivered and Sensitized by Nanoscale Coordination Polymers ACS Nano, 12 (8), 7519-7528 (2018)
[10] Yu Chao, Guanglin Wang, Chao Liang, Xuan Yi, Xiaoyan Zhong, Jingjing Liu, Min Gao, Kai Yang*, Liang Cheng*, Zhuang Liu*. “Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-Sensitized, Near-Infrared Enhanced Radioisotope Therapy” Small, 12, 3967-3975 (2016)
Email: ychao@suda.edu.cn
Edited by Juan Yang
