Presenter:Dr. JonathanF. Lovell, Assistant Professor, StateUniversity of New York at Buffalo
Topic: Imaging andDrug Delivery with New Self-Assembly Strategies
Time: 10:00 AM, July 6th
Location: Room 308, BLDG 910-3F
Abstract
Here, we will discuss our recentefforts to form nanoparticles with high-density payloads. In particular, wewill discuss two recently reported nanoscale systems, both involvinghigh-density porphyrin constructs. First, porphyrin nanovesicles have beendeveloped that can release drugs in response to laser irradiation and bind tohis-tagged proteins, leading to enhanced drug deposition in irradiated tumors.Second, using low-temperature "surfactant-stripping" a family of highlylight-absorbing nanoparticles (solutions with near infrared absorbance of >1000) have been developed for safe and real-time gastrointestinal imagingfollowing oral administration to mice. This same strategy was used to generatetherapeutic micelles with drug-to-excipient ratios multiple orders of magnitudehigher than current clinical formulations.
Biography
Jonathan F. Lovell is an assistantProfessor of Biomedical Engineering at the State University of New York atBuffalo. He received his Ph.D. in Biomedical Engineering from the University ofToronto in 2012. He was awarded the NIH Early Independence Award in 2013, theRita Schaffer Young Investigator Award of the Biomedical Engineering Society in2015 and an NSF CAREER award in 2016. He has published over 60 peer reviewedworks, including in Cell, Nature Materials, Nature Nanotechnology, NatureChemistry and Nature Communications. His main focus is on developingtranslatable nanoplatforms with applications in photomedicine, drug delivery,theranostic imaging and vaccine research.
Contact:Zhuang Liu
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