题目：

Simultaneous Capture, Detection, and Inactivation of Bacteria as

Enabled by a Surface-Enhanced Raman Scattering Multifunctional

Chip**

作者：

[*] Dr. H. Wang,[+] Dr. Y. Zhou,[+] X. Jiang,[+] B. Sun, Y. Zhu, H. Wang, Dr. Y. Su, Prof. Y. He

单位：

Institute of Functional Nano & Soft Materials (FUNSOM) and

Collaborative Innovation Center of Suzhou Nanoscience and

Technology (NANO-CIC), Soochow University

Suzhou 215123 (China)

摘要：

Herein, we present a multifunctional chip based on surface-enhanced Raman scattering (SERS) that effectively captures, discriminates, and inactivates pathogenic bacteria. The developed SERS chip is made of a silicon wafer decorated with silver nanoparticles and modified with 4-mercaptophenylboronic acid (4-MPBA). It was prepared in a straightforward manner by chemical reduction assisted by hydrogen fluoride etching, followed by the conjugation of 4-MPBA through Ag[1]S bonds. The dominant merits of the fabricated SERS chip include excellent reproducibility with a relative standard deviation (RSD) value smaller than 11.0%, adaptable bacterial-capture efficiency (ca. 60%) at low concentrations (500�2000 CFUmL[1]1), a low detection limit (down to a concentration of 1.0 [1] 102 cellsmL[1]1), and high antibacterial activity (an antibacterial rate of ca. 97%). The SERS chip enabled sensitive and specific discrimination of Escherichia coli and Staphylococcus aureus from human blood.

影响因子：

11.336

分区情况：

1区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/anie.201502752/abstract