题目：

Imaging-Guided Combined Photothermal and Radiotherapy to Treat Subcutaneous and Metastatic Tumors Using Iodine-131-Doped Copper Sulfi de Nanoparticles

作者：

Xuan Yi , Kai Yang , * Chao Liang , Xiaoyan Zhong , Ping Ning , Guosheng Song ,

Dongliang Wang , Cuicui Ge , Chunying Chen , Zhifang Chai , and Zhuang Liu *

单位：

X. Yi, Prof. K. Yang, X. Zhong, P. Ning, Prof. C. Ge, Prof. Z. Chai, School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Medical College of Soochow University, Suzhou , Jiangsu 215123 , China

C. Liang, Dr. G. Song, Prof. Z. Liu, Institute of Functional Nano and Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou , Jiangsu 215123 , China

Dr. D. Wang, Prof. C. Chen, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China

摘要：

Combining different therapeutic strategies to treat cancer by overcoming limitations of conventional cancer therapies has shown great promise in both fundamental and clinical studies. Herein, by adding 131 I when making iodinedoped CuS nanoparticles, CuS/[ 131 I]I nanoparticles are obtained, which after functionalization with polyethylene glycol (PEG) are used for radiotherapy (RT) and photothermal therapy (PTT), by utilizing their intrinsic high near-infrared absorbance and the doped 131 I-radioactivity, respectively. The combined RT and PTT based on CuS/[ 131 I]I-PEG is then conducted, achieving remarkable synergistic therapeutic effects as demonstrated in the treatment of subcutaneous tumors. In the meanwhile, as revealed by bimodal nuclear imaging and computed tomography (CT) imaging, it is found that CuS/[ 131 I]I-PEG nanoparticles after being injected into primary solid tumors could migrate to and retain in their nearby sentinel lymph nodes. Importantly, the combined RT and PTT applied on those lymph nodes to assist surgical resection of primary tumors results in remarkably inhibited cancer metastasis and greatly prolonged animal survival. In vivo toxicology studies further reveal that our CuS/I-PEG is not obviously toxic to animals at fourfold of the treatment dose. This work thus demonstrates the potential of combining RT and PTT using a single nanoagent for imaging-guided treatment of metastatic tumors.

影响因子：

10.439

分区情况：

1区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/adfm.201502003/abstract