题目：

FeSe₂ -Decorated Bi₂ Se₃ Nanosheets Fabricated via Cation Exchange for Chelator-Free ⁶⁴Cu-Labeling and Multimodal Image-Guided Photothermal-Radiation Therapy

作者：

Liang Cheng , * Sida Shen , Sixiang Shi , Yuan Yi , Xiaoyong Wang , Guosheng Song , Kai Yang , Gang Liu , Todd E. Barnhart , Weibo Cai , * and Zhuang Liu *

单位：

Institute of Functional Nano and Soft Materials Laboratory (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University

Department of Radiology, University of Wisconsin�Madison Madison , WI , USA

School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X) Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection Soochow University

Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen , Fujian 361005 , P.R. China

摘要：

Multifunctional theranostic agents have become rather attractive to realize image-guided combination cancer therapy. Herein, a novel method is developed to synthesize Bi₂ Se₃ nanosheets decorated with mono-dispersed FeSe₂ nanoparticles (FeSe₂ /Bi₂ Se₃ ) for tetra-modal image-guided combined photothermal and radiation tumor therapy. Interestingly, upon addition of Bi(NO₃ )₃ , pre-made FeSe₂ nanoparticles via cation exchange would be gradually converted into Bi₂ Se₃ nanosheets, on which remaining FeSe₂ nanoparticles are decorated. The yielded FeSe₂ /Bi₂ Se₃ composite-nanostructures are then modified with polyethylene glycol (PEG). Taking advantages of the high r₂ relaxivity of FeSe₂ , the X-ray attenuation ability of Bi₂ Se₃ , the strong near-infrared optical absorbance of the whole nanostructure, as well as the chelate-free radiolabeling of ⁶⁴Cu on FeSe₂ /Bi₂ Se₃ -PEG, in vivo magnetic resonance/computer tomography/photoacoustic/position emission tomography multimodal imaging is carried out, revealing efficient tumor homing of FeSe₂ /Bi₂ Se₃ -PEG after intravenous injection. Utilizing the intrinsic physical properties of FeSe₂ /Bi₂ Se₃ -PEG, in vivo photothermal and radiation therapy to achieve synergistic tumor destruction is then realized, without causing obvious toxicity to the treated animals. This work presents a unique method to synthesize composite-nanostructures with highly integrated functionalities, promising not only for nano-biomedicine but also potentially for other different nanotechnology fields.

影响因子：

11.805

分区情况：

1区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/adfm.201504810/full