题目：

Ultrasensitive, Specific, Recyclable, and Reproducible Detection of Lead Ions in Real Systems through a Polyadenine-Assisted, Surface-Enhanced Raman Scattering Silicon Chip

作者：

Yu Shi,^† Houyu Wang,^† Xiangxu Jiang, Bin Sun, Bin Song, Yuanyuan Su, and Yao He*

单位：

Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China

摘要：

It is of great significance to accurately and reliably detect trace lead(II) (Pb²⁺) ions, preferably at sub-nM level due to the possible long-term accumulation of Pb²⁺ in the human body, which may cause serious threats to human health. However, a suitable Pb²⁺ sensor meeting the demands is still scanty. Herein, we develop a polyadenine-assisted, surface-enhanced Raman scattering (SERS) silicon chip (0.5 cm × 0.5 cm) composed of core (Ag)-satellite (Au) nanoparticles (Ag−Au NPs)-decorated silicon wafers (Ag−Au NPs@Si) for high-performance Pb²⁺ detection. Typically, strong SERS signals could be measured when DNAzyme conjugated on the SERS silicon chip is specifically activated by Pb²⁺, cleaving the substrate strand into two free DNA strands. A good linearity exists between the normalized Raman intensities and the logarithmic concentrations of Pb²⁺ ranging from 10 pM to 1 μM with a good correlation coefficient, R² of 0.997. Remarkably, Pb²⁺ ions with a low concentration of 8.9 × 10⁻¹² M can be readily determined via the SERS silicon chip ascribed to its superior SERS enhancement, much lower than those (∼nM) reported by other SERS sensors. Additionally, the developed chip features good selectivity and recyclability (e.g., ∼11.1% loss of Raman intensity after three cycles). More importantly, the as-prepared chip can be used for accurate and reliable determination of unknown Pb²⁺ ions in real systems including lake water, tap water and industrial wastewater, with the RSD value less than 12%.

影响因子：

5.636

分区情况：

2区

链接：

http://dx.doi.org/10.1021/acs.analchem.5b04551