题目：

Albumin-NIR Dye Self-Assembled Nanoparticles for Photoacoustic pH Imaging and pH-Responsive Photothermal Therapy Effective for Large Tumors

作者：

Qian Chen^a, Xiaodong Liu^b, Jianfeng Zeng^c, Zhenping Cheng^b, Zhuang Liu^a,*

单位：

 摘要：      

^aInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, China

^bDepartment of Polymer Science and Engineering, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu, 215123, China

^cSchool of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, 215123, China

Real-time in vivo pH imaging in the tumor, as well as designing therapies responsive to the acidic tumor microenvironment to achieve optimized therapeutic outcomes have been of great interests in the field of nanomedicine. Herein, a pH-responsive near-infrared (NIR) croconine (Croc) dye is able to induce the self-assembly of human serum albumin (HSA) to form HSA-Croc nanoparticles useful not only for realtime ratiometric photoacoustic pH imaging of the tumor, but also for pH responsive photothermal therapy with unexpected great performance against tumors with relatively large sizes. Such HSA-Croc nanoparticles upon intravenous injection exhibit efficient tumor homing. As the decrease of pH, the absorption of Croc at 810 nm would increase while that at 680 nm would decrease, allowing real-time pH sensing in the tumor by double-wavelength ratiometric photoacoustic imaging, which reveals the largely decreased pH inside the cores of large tumors.

影响因子：

8.557

分区情况：

1区

链接：

http://www.sciencedirect.com/science/article/pii/S0142961216301600

(责任编辑：杨阳，联系方式：yangyangcnst@suda.edu.cn)