题目：

Nanoscale Metal−Organic Frameworks for Combined Photodynamic & Radiation Therapy in Cancer Treatment

作者：

Jingjing Liu^a, Yu Yang^b, Wenwen Zhu^a, Xuan Yi^c, Ziliang Dong^a, Xiaona Xu^a, Meiwan Chen^b, Kai Yang^c, Guang Lu^a, Lixin Jiang^d,**, Zhuang Liu^a,*

单位：

摘要：      

^aInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China

^bState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidad, Taipa, Macau, China

^cSchool of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu, 215123, China

^dDepartment of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated, No.6 Hospital Yishan Road 600, Shanghai, 200233, China

We report the rational design of a NMOF composed by hafnium (Hf⁴⁺) and tetrakis (4-carboxyphenyl) porphyrin (TCPP). In such Hf-TCPP NMOFs, while TCPP is a photosensitizer to allow photodynamic therapy (PDT), Hf⁴⁺ with strong X-ray attenuation ability could serve as a radio-sensitizer to enhance radiotherapy (RT). Those NMOFs with polyethylene glycol (PEG) coating show efficient tumor homing upon intravenous injection, and thus could be used for in vivo combined RT & PDT, achieving a remarkable anti-tumor effect. Importantly, Hf-TCPP NMOFs show efficient clearance from the mouse body, minimizing concerns regarding their possible long-term toxicity.

影响因子：

8.557

分区情况：

1区

链接：

http://www.sciencedirect.com/science/article/pii/S0142961216301454

(责任编辑：杨阳，联系方式：yangyangcnst@suda.edu.cn)