题目：

Facile Preparation of Multifunctional WS₂/WO_x Nanodots for Chelator-Free ⁸⁹Zr-Labeling and In Vivo PET Imaging

作者：

Liang Cheng, Anyanee Kamkaew, Sida Shen, Hector F. Valdovinos, Haiyan Sun, Reinier Hernandez, Shreya Goel, Teng Liu, Cyrus R. Thompson, Todd E. Barnhart, Zhuang Liu*, Weibo Cai*

单位：

摘要：      

Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou, Jiangsu 215123, China

Department of Radiology University of Wisconsin-Madison WI 53705, USA

While position emission tomography (PET) is an important molecular imaging technique for both preclinical research and clinical disease diagnosis/prognosis, chelator-free radiolabeling has emerged as a promising alternative approach to label biomolecules or nanoprobes in a facile way. Herein, starting from bottom-up synthesized WS₂ nanoflakes, this study fabricates a unique type of WS₂/WO_x nanodots, which can function as inherent hard oxygen donor for stable radiolabeling with Zirconium-89 isotope (⁸⁹Zr). Upon simply mixing, ⁸⁹Zr can be anchored on the surface of polyethylene glycol (PEG) modified WS₂/WOx (WS₂/WO_x-PEG) nanodots via a chelator-free method with surprisingly high labeling yield and great stability. A higher degree of oxidation in the WS₂/WO_x-PEG sample (WS₂/WO_x (0.4)) produces more electron pairs, which would be beneficial for chelator-free labeling of ⁸⁹Zr with higher yields, suggesting the importance of surface chemistry and particle composition to the efficiency of chelator-free radiolabeling. Such ⁸⁹Zr-WS₂/WO_x (0.4)-PEG nanodots are found to be an excellent PET contrast agent for in vivo imaging of tumors upon intravenous administration, or mapping of draining lymph nodes after local injection.

影响因子：

8.315

分区情况：

一区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/smll.201601696/full