题目：

Modulation of Hypoxia in Solid Tumor Microenvironment with MnO₂ Nanoparticles to Enhance Photodynamic Therapy

作者：

Wenwen Zhu, Ziliang Dong, Tingting Fu, Jingjing Liu, Qian Chen, Yonggang Li, Ran Zhu*, Ligeng Xu*, Zhuang Liu*

单位：

摘要：      

Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University 199 Ren’ai Road, Suzhou 215123, Jiangsu, P. R. China

Hypoxia not only promotes tumor metastasis but also strengthens tumor resistance to therapies that demand the involvement of oxygen, such as radiation therapy and photodynamic therapy (PDT). Herein, taking advantage of the high reactivity of manganese dioxide (MnO₂) nanoparticles toward endogenous hydrogen peroxide (H₂O₂) within the tumor microenvironment to generate O₂, multifunctional chlorine e6 (Ce6) loaded MnO₂ nanoparticles with surface polyethylene glycol (PEG) modification (Ce6@MnO₂-PEG) are formulated to achieve enhanced tumor-specific PDT. In vitro studies under an oxygen-deficient atmosphere uncover that Ce6@MnO₂-PEG nanoparticles could effectively enhance the efficacy of light-induced PDT due to the increased intracellular O₂ level benefited from the reaction between MnO₂ and H₂O₂, the latter of which is produced by cancer cells under the hypoxic condition. Owing to the efficient tumor homing of Ce6@MnO₂-PEG nanoparticles upon intravenous injection as revealed by T1-weighted magnetic resonance imaging, the intratumoral hypoxia is alleviated to a great extent. Thus, in vivo PDT with Ce6@MnO₂-PEG nanoparticles even at a largely reduced dose offers remarkably improved therapeutic efficacy in inhibiting tumor growth compared to free Ce6. The results highlight the promise of modulating unfavorable tumor microenvironment with nanotechnology to overcome current limitations of cancer therapies.

影响因子：

11.382

分区情况：

一区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/adfm.201600676/full

（责任编辑：向丹婷 联系方式：dtxiang@suda.edu.cn）