题目：

In Vivo Long-Term Biodistribution, Excretion, and Toxicology of PEGylated Transition-Metal Dichalcogenides MS₂ (M = Mo, W, Ti) Nanosheets

作者：

Jiali Hao, Guosheng Song, Teng Liu, Xuan Yi, Kai Yang, Liang Cheng,* and Zhuang Liu*

单位：

  摘要：      

Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, P. R. China

School of Radiation Medicine and Protection & Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu 215123, China

In vivo behaviors of three representative TMDCs including molybdenum dichalcogenides (MoS₂), tungsten dichalcogenides (WS₂), and titanium dichalcogenides (TiS₂) nanosheets are systematically investigated. Without showing significant in vitro cytotoxicity, all the three types of polyethylene glycol (PEG) functionalized TMDCs show dominate accumulation in reticuloendothelial systems (RES) such as liver and spleen after intravenous injection. In marked contrast to WS₂-PEG and TiS₂-PEG, which show high levels in the organs for months, MoS₂-PEG can be degraded and then excreted almost completely within one month. Further degradation experiments indicate that the distinctive in vivo excretion behaviors of TDMCs can be attributed to their different chemical properties. This work suggests that MoS₂, among various TMDCs, may be particularly interesting for further biomedical applications owning to its low toxicity, capability of biodegradation, and rapid excretion.

影响因子：

6.0

分区情况：

一区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/advs.201600160/full

（责任编辑：向丹婷 联系方式：dtxiang@suda.edu.cn）