题目：

Drug-Loaded Mesoporous Tantalum Oxide Nanoparticlesfor Enhanced Synergetic Chemoradiotherapy withReduced Systemic Toxicity

作者：

Yuyan Chen, Guosheng Song, *Ziliang Dong, Xuan Yi, Yu Chao, Chao Liang,Kai Yang, Liang Cheng, and Zhuang Liu*

单位：

 摘要：

Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou NanoScience and Technology, the Jiangsu Key Laboratoryfor Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China

Combining chemotherapy and radiotherapy (chemoradiotherapy) has been widely applied in many clinical practices, showing promises in enhancing therapeuticoutcomes. Nontoxic nanocarriers that not only are able to deliver chemotherapeuticsinto tumors, but could also act as radiosensitizers to enhance radiotherapy wouldthus be of great interest in the development of chemoradiotherapies. To achieve thisaim, herein mesoporous tantalum oxide (mTa₂O₅) nanoparticles with polyethyleneglycol (PEG) modification are fabricated. Those mTa₂O₅-PEG nanoparticles couldserve as a drug delivery vehicle to allow efficient loading of chemotherapeutics suchas doxorubicin (DOX), whose release appears to be pH responsive. Meanwhile,owing to the interaction of Ta with X-ray, mTa₂O₅-PEG nanoparticles could offeran intrinsic radiosensitization effect to increase X-ray-induced DNA damagesduring radiotherapy. As a result, DOX-loaded mTa₂O₅-PEG (mTa₂O₅-PEG/DOX) nanoparticles can offer a strong synergistic therapeutic effect during the combined chemoradiotherapy. Furthermore, in chemoradiotherapy, such mTa₂O₅-PEG/DOX shows remarkably reduced side effects compared to free DOX, which at thesame dose appears to be lethal to animals. This work thus presents a new type of mesoporous nanocarrier particularly useful for the delivery of safe and effective chemoradiotherapy.

影响因子：

8.315

分区情况：

1区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/smll.201602869/full