| 单位： 摘要： | School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center ofRadiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu, 215123, China Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University,Suzhou, Jiangsu, 215123, China Development of biocompatible/biodegradable materials with multiple functionalities via simplemethods for cancer combination therapy has attracted great attention in recent years. Herein,paclitaxel (PTX), a popular anti-tumor chemotherapeutic drug, is used to induce the self-assemblyof human serum albumin (HSA) pre-labeled with radionuclide I-131, obtaining 131I-HSA-PTXnanoparticles for combined chemotherapy and radioisotope therapy (RIT) of cancer. Such131I-HSA-PTX nanoparticles show prolonged blood circulation time, high tumor specific uptake andexcellent intra-tumor penetration ability. Interestingly, as revealed by in vivo photoacoustic imaging and ex vivo immunofluorescence staining, PTX delivered into the tumor byHSA-nanoparticle transportation can remarkably enhance the tumor local oxygen level andsuppress the expression of HIF-1α, leading to greatly relieved tumor hypoxia. As the results, thecombined in vivo chemotherapy & RIT with 131I-HSA-PTX nanoparticles in the animal tumor modeloffers excellent synergistic therapeutic efficacy, likely owing to the greatly modulated tumormicroenvironment associated with PTX-based chemotherapy. Therefore, in this work, a simpleyet effective therapeutic agent is developed for synergistic chemo-RIT of cancer, promising forfuture clinic translations in cancer treatment. |
