题目：

Core-shelland co-doped nanoscale metal-organicparticles (NMOPs) obtained via post-synthesis cationexchange for multimodal imaging and synergisticthermo-radiotherapy

作者：

Yu Yang¹, Yu Chao², Jingjing Liu², Ziliang Dong², Weiwei He³, Rui Zhang², Kai Yang³, Meiwan Chen¹and Zhuang Liu²

单位：

摘要：

¹State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Macau, China;

²Institute ofFunctional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Jiangsu, China

³School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Jiangsu, China

Nanoscale metal-organic particles (NMOPs) have recently shown great promise in the area of nanomedicine owing to their tunable compositions, highly enriched functionalities, well-defined sizes/shapes and intrinsic biodegradability. Herein, wedescribe the fabrication of NMOPs with both core-shell and co-doped structures via a post-synthesis cation exchange method for applications in multimodal imaging and combined photothermal and radiation therapy of cancer. Template NMOPs containingMn²⁺ and IR825, a near-infrared (NIR) dye, are first synthesized and then mixed with Hf⁴⁺ to obtain core-shell and co-doped Mn/Hf-IR825 NMOPs depending on the dose of added Hf⁴⁺ ions. In these NMOPs, Mn²⁺ offers strong T1 magnetic resonance(MR) contrast, Hf⁴⁺ is a high-Z element with excellent computed tomography signal enhancement ability and radio-sensitizationcapability, and IR825 exhibits rather high NIR absorbance. After coating with polydopamine (PDA) and further conjugation withpolyethylene glycol (PEG), the co-doped Mn/Hf-IR825@PDA-PEG particles (NMOP-PEG) showed efficient tumor-homing abilityafter intravenous injection, as illustrated by MR and photoacoustic (PA) imaging. Utilizing NMOP-PEG achieved excellent tumorkilling efficacy through in vivo photothermal and radiation synergistic therapy in our mouse tumor model experiments.Importantly, our NMOP-PEG showed no appreciable toxicity to the treated mice and could be efficiently excreted. Our workpresents a facile method to fabricate NMOP-PEG with multi-component structures as a biodegradable, multifunctional nanoplatform for multimodal image-guided combination cancer therapy.

影响因子：

8.772

分区情况：

1区

链接：

http://www.nature.com/am/journal/v9/n1/pdf/am2016205a.pdf