| 作者： | Liangzhu Feng, Danlei Tao, Ziliang Dong, Qian Chen, Yu Chao, Zhuang Liu2*, MeiwanChen1* |
| 单位： 摘要： | State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese MedicalSciences, University of Macau, Macau 999078, China Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory forCarbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China Current photodynamic therapy (PDT) is suffering from limited efficacy towards hypoxia tumorsand severe post-treatment photo-toxicity such as light-induced skin damages. To make PDT moreeffective in cancer treatment while being patient-comfortable, herein, a hexylamine conjugated chlorin e6 (hCe6) as the photosensitizer together with a lipophilic near-infrared (NIR) dye1,1'-dioctadecyl-3,3,3',3' -tetramethylindotricarbocyanine iodide (DiR) are co-encapsulated into polyethylene glycol (PEG) shelled liposomes. In the obtained DiR-hCe6-liposome, thephotosensitizing effect of hCe6 is quenched by DiR via fluorescence resonance energy transfer(FRET). Interestingly, upon irradiation with a 785-nm NIR laser to photobleach DiR, both fluorescence and photodynamic effect of hCe6 in DiR-hCe6-liposome would be activated.Meanwhile, such NIR irradiation applied on tumors of mice with intravenous injection of DiR-hCe6-liposome could result in mild photothermal heating, which in turn would promoteintra-tumor blood flow and relieve tumor hypoxia, contributing to the enhanced photodynamictumor treatment. Importantly, compared to hCe6-loaded liposomes, DiR-hCe6-liposome withoutbeing activated by the 785-nm laser shows much lower skin photo-toxicity, demonstrating its greats skin protection effect. This work demonstrates a promising yet simple strategy to prepare NIR-light-activatable photodynamic theranostics for synergistic cancer phototherapy, which isfeatured high specificity/efficacy in tumor treatment with minimal photo-toxicity towards the skin. |
