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刘庄教授课题组在Biomaterials上发表论文
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发布时间：2017-03-10 点击：1016
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| 题目： | TaOx decorated perfluorocarbon nanodroplets as oxygen reservoirs to overcome tumor hypoxia and enhance cancer radiotherapy | | 作者： | Guosheng Song a, 1, ChenghongJib, 1, Chao Liang a, Xuejiao Song a, Xuan Yi c,Ziliang Dong a, Kai Yang c, Zhuang Liu a, * | | 单位： | aInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow UniversitySuzhou, Jiangsu 215123, China bDepartment of Respiratory Diseases, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China cSchool of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X) Medical College of Soochow University Suzhou, Jiangsu 215123, China | | 摘要： | Cancer radiotherapy (RT) is a clinically used tumor treatment strategy applicable for a wide range of solidtumors. However, during RT treatment of tumors, only a small portion of applied ionizing irradiationenergy is absorbed by the tumor, in which the largely hypoxic microenvironment also limits the antitumorefficacy of RT. In this work, we rationally fabricate polyethylene glycol (PEG) stabilized perfluorocarbon(PFC) nano-droplets decorated with TaOx nanoparticles (TaOx@PFC-PEG) as a multifunctionalRT sensitizer. The obtained TaOx@PFC-PEG nanoparticles on one hand can absorb X-ray by TaOx to concentrate radiation energy within tumor cells, on the other hand after saturating PFC with oxygen willact as an oxygen reservoir to gradually release oxygen and improve tumor oxygenation. As the result,remarkably enhanced in vivo RT treatment is achieved with TaOx@PFC-PEG nanoparticles in our mousetumor model experiments. Our work thus presents a new nanotechnology strategy to enhance RT induced tumor treatment by simultaneously concentrating radiation energy within tumors andimproving tumor oxygenation, using one multifunctional agent. | |
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