题目：

Mitochondria-Targeting Au Nanoclusters Enhance Radiosensitivity of Cancer Cells

作者：

Xu Fang,^a Yaling Wang,^b Xiaochuan Ma,^*c Yingying Li,^a Zhaolei Zhang,^a Zhisheng Xiao,^a Lijia Liu,^a Xueyun Gao^b and Jian Liu ^*a

单位：

^a Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China.

^b Institute of High Energy Physics, Chinese Academy of Sciences, Beijing100049, China

^c School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China.

摘要：

Radiotherapy is an important technology for the clinical treatment of cancer, but the patients suffer from the severe side effects after exposure to radiation. There is an urgent need to develop theranostic agents with excellent imaging capability and effective radiosensitization in order to minimize X-ray irradiation. Herein, we report an approach to synthesize peptide-templated Au nanoclusters (AuNCs) for theranostic radiosensitization. A new peptide (CCYKFR) is designed for the preparation of AuNCs with uniform size distribution and fluorescence (656 nm) of high photostability. CCYKFR�AuNCs feature highly efficient targeting/accumulation on mitochondria after endocytosis. With a series of experiments, we demonstrate that CCYKFR�AuNCs irradiated by 4 Gy X-rays can introduce a burst of mitoROS and severe DNA damage leading to cancer cell death. This study presents an important strategy to design theranostic nanomaterials with improved radiosensitization for the development of new anti-cancer therapies.

影响 

因子：

4.872

分区情况：

一区

链接：  

http://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb00422b#!divAbstract

责任编辑：向丹婷 联系方式：dtxiang@suda.edu.cn