题目：

Albumin-Templated Manganese Dioxide Nanoparticles for Enhanced Radioisotope Therapy

作者：

Longlong Tian¹, Qian Chen¹, Xuan Yi², Jiawen Chen¹, Chao Liang¹, Yu Chao¹, Kai Yang,*²and Zhuang Liu*¹

单位：

¹Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Collaborative Innovation Center of Suzhou, Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China

²School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu 215123, China

摘要：      

Although nanoparticle-based drug delivery systems have been widely explored for tumor-targeted delivery of radioisotope therapy (RIT), the hypoxia zones of tumors on one hand can hardly be reached by nanoparticles with relatively large sizes due to their limited intratumoral diffusion ability, on the other hand often exhibit hypoxiaassociated resistance to radiation-induced cell damage. To improve RIT treatment of solid tumors, herein, radionuclide ¹³¹I labeled human serum albumin (HSA)-bound manganese dioxide nanoparticles (¹³¹I-HSA-MnO₂) are developed as a novel RIT nanomedicine platform that is responsive to the tumor microenvironment (TME).Such ¹³¹I-HSA-MnO₂ nanoparticles with suitable sizes during blood circulation show rather efficient tumor passive uptake owing to the enhanced permeability and retention effect, as well as little retention in other normal organs to minimize radiotoxicity. The acidic TME can trigger gradual degradation of MnO₂ and thus decomposition of ¹³¹I-HSA-MnO₂ nanoparticles into individual ¹³¹I-HSA withsub-10 nm sizes and greatly improves intratumoral diffusion. Furthermore, oxygen produced by MnO₂-triggered decomposition of tumor endogenous H₂O₂ would be helpful to relieve hypoxia-associated RIT resistant for those tumors. As the results, the ¹³¹I-HSA-MnO₂ nanoparticles appear to be a highly effective RIT agent showing great efficacy in tumor treatment upon systemic administration.

影响因子：

8.643

分区情况：

1区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/smll.201700640/full

责任编辑：向丹婷 联系方式：dtxiang@suda.edu.cn