题目：

Catalase-Loaded Cisplatin-Prodrug-Constructed Liposomes to Overcome Tumor Hypoxia for Enhanced Chemo-Radiotherapy of Cancer

作者：

Rui Zhang¹, Xuejiao Song¹, Chao Liang¹, Xuan Yi², Guosheng Song¹, Yu Chao¹,Yu Yang¹, Kai Yang², Liangzhu Feng¹, **, Zhuang Liu¹, *

单位：

¹Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China

²School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, China

摘要：      

Aiming at improved therapeutic efficacies, the combination of chemotherapy and radiotherapy (chemoradiotherapy) has been widely studied and applied in clinic. However, the hostile characteristics of tumor microenvironment such as hypoxia often limit the efficacies in both types of cancer therapies. Herein, catalase (CAT), an antioxidant enzyme, is encapsulated inside liposomes constituted by cisplatin (IV)-

prodrug-conjugated phospholipid, forming CAT@Pt (IV)-liposome for enhanced chemo-radiotherapy of cancer. After being loaded inside liposomes, CAT within CAT@Pt (IV)-liposome shows retained and wellprotected enzyme activity, and is able to trigger decomposition of H₂O₂ produced by tumor cells, so as to produce additional oxygen for hypoxia relief. As the result, treatment of CAT@Pt(IV)-liposome induces the highest level of DNA damage in cancer cells after X-ray radiation compared to the control groups. In vivo tumor treatment further demonstrates a remarkably improved therapeutic outcome in chemoradiotherapy with such CAT@Pt (IV)-liposome nanoparticles. Hence, an exquisite type of liposomebased nanoparticles is developed in this work by integrating cisplatin-based chemotherapy and catalase-induced tumor hypoxia relief together for combined chemo-radiotherapy with great synergistic efficacy, promising for clinical translation in cancer treatment.

影响因子：

8.402

分区情况：

1区

链接：

http://www.sciencedirect.com/science/article/pii/S0142961217303435

责任编辑：向丹婷 联系方式：dtxiang@suda.edu.cn