题目：

Ultra-Small Iron-Gallic Acid Coordination Polymer Nanoparticles for Chelator-Free Labeling of ⁶⁴Cu and Multimodal Imaging-Guided Photothermal Therapy

作者：

QiutongJin,^a WenjunZhu,^a Dawei Jiang,^b,c Rui Zhang,^a Christopher J. Kutyreff,^b Jonathan W. Engle,^b Peng Huang,^c Weibo Cai,^*b Zhuang Liu^a and Liang Cheng^*a

单位：

^aInstitute of Functional Nano & Soft Materials (FUNSOM), College of Nano Science & Technology (CNST), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.

^bDepartment of Radiology University of Wisconsin-Madison Madison, WI 53705, USA

^cGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China

摘要：

Cancer nanotechnology has become the hot topic nowadays. While various kinds of nanomaterials have been widely explored for innovative cancer imaging and therapy applications, safe multifunctional nanoagents without long-term retention and toxicity are still demanded. Herein, iron-gallic acid coordination nanoparticles (Fe-GA CPNs) with ultra-small sizes are successfully synthesized by a simple method for multimodal imaging-guided cancer therapy. After surface modification with polyethylene glycol (PEG), the synthesized Fe-GA-PEG CPNs show high stability in various physiological solutions. Taking advantage of high near-infrared (NIR) absorbance as well as the T1-MR contrasting ability of Fe-GA-PEG CPNs, in vivo photoacoustic tomography (PAT) and magnetic resonance (MR) bimodal imaging are carried out, revealing the efficient passive tumor targeting of these ultra-small CPNs after intravenous (i.v.) injection. Interestingly, such Fe-GA-PEG CPNs could be labeled with the ⁶⁴Cu isotope via a chelator-free method for in vivo PET imaging, which also illustrates the high tumor uptake of Fe-GA CPNs. We further utilize Fe-GA-PEG CPNs for in vivo photothermal therapy and achieve highly effective tumor destruction after i.v. injection of Fe-GA-PEG CPNs and the following NIR laser irradiation of the tumors, without observing any apparent toxicity of such CPNs to the treated animals. Our work highlights the promise of ultra-small iron coordination nanoparticles for imaging-guided cancer therapy

影响因子：

7.760

分区情况：

一区

链接：

http://pubs.rsc.org/en/content/articlehtml/2017/nr/c7nr03086j