题目：

Albumin-Templated Biomineralizing Growth of Composite Nanoparticles as Smart Nanotheranostics for Enhanced Radiotherapy of Tumors

作者：

Jiawen Chen,^a Qian Chen,^*a Chao Liang,^a ZhijuanYang,^a Lin Zhang,^b XuanYi,^c Ziliang Dong,^a Yu Chao,^a Youguo Chen*^b and Zhuang Liu*^a

单位：

^aInstitute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbonbased

Functional Materials and Devices, Soochow University, Suzhou, Jiangsu,215123, China.

^bDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of SoochowUniversity, Suzhou 215006, China.

^cSchool of Radiation Medicine and Protection & School for Radiological andInterdisciplinary Sciences (RAD-X), Collaborative Innovation Center of RadiationMedicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou215123, China.

摘要：

Hypoxia and a dense extracellular matrix within the tumor microenvironment can often lead to the resistanceof tumors to radiotherapy. Herein, we use bovine serum albumin (BSA) as a template to induce the growth of both gold (Au) nanoclusters and manganese dioxide (MnO₂) via biomineralization. In the obtained BSA-Au-MnO₂ composite nanoparticles, Au nanoclusters embedded within BSA not only show strong red fluorescence to facilitate imaging, but also act as a radio-sensitizer by absorbing and depositing X-ray energy within tumors to enhance radiotherapy. Meanwhile, the MnO₂ core, which enables the formation of composite nanoparticles by connecting multiple albumins together, is able to modulate the tumor hypoxia by triggering the decomposition of tumor endogenous H₂O₂ into oxygen, so as to reverse the hypoxia-associated radiation resistance of tumors. Notably, such BSA-Au-MnO₂ composite nanoparticles with larger sizes show prolonged blood circulation and increased tumor accumulation compared to BSA-Au complexes, and would dissociate back into individual BSA-Au complexes once inside the tumor with reduced pH to allow deep interstitial diffusion. As a result, highly effective radiotherapy of tumors is realized with these nanoparticles in a mouse tumor model. Our work thus presents a convenient biomineralization approach to fabricate intelligent multifunctional nanoparticles composed of biocompatible/biodegradable components for enhanced cancer therapy.

影响因子：

7.367

分区情况：

一区

链接：

http://pubs.rsc.org/en/content/articlehtml/2017/nr/c7nr05316a