University of North Carolina at Chapel Hill, USA

Title：Lipid-Stabilized Nano-Precipitates for Drug and Gene Delivery

Time：10:00AM, Sep.28^th (Monday)

Location: Conference Room B, BLDG 909-1F

Abstract:

A new class of nanoparticle consisting of an insoluble core wrapped by a single lipid bilayer has been developed to deliver small anti-cancer drugs and nucleic acids including pDNA, mRNA and siRNA. The physical and biological properties of the lipid-stabilized nano-precipitates will be discussed. Their application in chemotherapy and cancer immunotherapy will also be presented.

Short-biography:

黄力夫教授Leaf Huang, Ph.D. is the Fred Eshelman Distinguished Professor, Division of Molecular Pharmaceutics in the Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Dr. Huang’s research has been in the area of gene therapy and targeted drug delivery. He has pioneered the liposome non-viral vector and has designed and manufactured the cationic lipid vector for the first non-viral clinical trial in 1992. His current work centers on nanoparticle vectors for gene transfer in tumor and liver. He also continues research in establishing a ligand targeted delivery system for cDNA, mRNA, siRNA, proteins and peptides for tumor growth inhibition and for vaccines in treating cancer and infected diseases.  He has authored or co-authored more than 500 papers with an H-index of 105. He is also the inventor or co-inventor of 17 US and foreign patents. In 2004, he received the Alec D. Bangham MD FRS Achievement Award, which is the highest honor in liposome research. He was the recipient of the 2013 Distinguished Pharmaceutical Scientist Award which is the highest scientific recognition of the American Association of Pharmaceutical Scientists. Dr. Huang has also co-founded 5 biotech start-ups in the past.

联络人： 刘庄 教授