Presenter：Prof. Kanyi Pu(浦侃裔), Associate Professor
School of Chemical and Biomedical Engineering
Nanyang Technological University, Singapore
Topic：OrganicSemiconducting Nanoparticles for Optical Theranostics
Time： 10：30AM,June 5th
Location：909-B
Abstract
Optical theranostic nanoagents that seamlessly and synergisticallyintegrate light-generated signals with photothermal or photodynamic therapy canprovide opportunities for cost-effective precision medicine, while thepotential for clinical translation requires them to have good biocompatibilityand high imaging/therapy performance. Semiconducting polymer nanoparticles (SPNs)have emerged as a category of new optical nanomaterials that can be easilytransformed from hydrophobic semiconducting polymers (SPs). Asoptoelectronically active SPs are completely organic and biologically benign,SPNs intrinsically circumvent the issue of heavy metal ion induced toxicity toliving organisms and thus possess good biocompatibility. In this talk, we willdemonstrate how to capitalize on the intraparticle engineering approach todevelop SPNs into theranostics for amplified imaging and therapeuticapplications. In particular, the design principle of the nanoparticles will berevealed along with their biomedical applications in photoacoustic imaging andphotothermal therapy of tumor in living mice. Our work not only introduces anew category of purely organic optical theranostics but also provides amolecular guideline to amplify the effectiveness of light-intensive imaging andtherapeutic nanosystems.
Biography
Dr. Pu joinedthe School of Chemical and Biomedical Engineering (SCBE) at NTU as an AssociateProfessor in June 2015. He did his MS (2007) with Prof. Wei Huang (CAS member)at Fudan University in China. He then came to Singapore and did his PhD (2011).He moved to Stanford University School of Medicine for his postdoctoral studyin 2011, under the supervision of Prof. Jianghong Rao and the directorship ofProf. Sanjiv Sam Gambhir at the molecular imaging program at Stanford (MIPS).As an active member of MIPS and the Center for Cancer Nanotechnology Excellenceand Translation (CCNE-T), he made significant contributions to organic polymerbased imaging probes and technologies, such as photoacoustic imaging,chemiluminescence imaging and in vivo imaging of reactive oxygen and nitrogenspecies.
Dr. Pu has published more than 60journal papers, 2 book chapters and 6 patents. With a h-index of 36, his workon molecular imaging and bio anotechnology has been highlighted by manyworld-renown scientific journals such as Nature Biotechnology, Nature Methods,and Cell Express el al..He has won a number of awards for his creative work,including a young investigator travel award and several best poster awards.
Contact: Zhuang Liu
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