Presenter: Prof. Qiaobing Xu (Tufts University)
Topic: Nanotechnology for DrugDelivery and Tissue Engineering
Time: 10:30 AM, Jul. 12th (Tuesday)
Location: Conference Room B, BLDG909-1F
Abstract
Biomaterials at nanoscale have been widely studied as novel vectors forcontrolled drug delivery and artificial matrices for tissue engineering. In my group, we are interested in developingmicro/nanotechnology for biomedical applications, including nanomedicine andtissue engineering. In the first part ofmy presentation, I will present the development of an effective strategy todeliver therapeutic proteins into cytoplasm for cancer treatment, using acombination of the reversible modification of proteins and cationic lipid-basednanoparticles. The application of such novel delivery system for the inhibitionof tumor cell proliferation both in vitro and in vivo will be demonstrated. Inthe second part of my talk, I will present a novel fabrication technique, called“Bioskiving” that we recently developed to fabricate tissue constructs fromdecellularized biological tissues. For example, we fabricated various 2D and 3Dconstructs from a piece of decelullarized tendon which comprises of bundles ofwell aligned collagen nanofibers using a combination of tissue sectioning,stacking and rolling. We have further extended this strategy to otherdecellularized tissues. Some potential biomedical applications, such as nerveconduits and blood vessels, of this novel fabrication strategy will bediscussed.
Biography
Dr. Qiaobing Xu is currently anassistant professor in Department of Biomedical Engineering at TuftsUniversity. He also holds adjunction assistant professor position in Departmentof Chemical and Biological Engineering and School of Medicine at TuftsUniversity. He was promoted to associated professor with tenure in May 2016. Heobtained his B.S. in 1999, and M.Sc. in 2002 (Advisor: Prof. Xi Zhang) bothfrom Department of Chemistry, Jilin University, Changchun, China. He obtained his PhD in chemistry under theguidance of Prof. George Whitesides from Harvard University where he invented“Nanoskiving”, a novel technology to fabricate functional nanomaterials. From 2007-2010, he was a Cancer Center forNanotechnology Excellence postdoctoral fellow with Prof. Robert Langer at MIT,where he worked on developing novel nanomaterials for drug deliveryapplications. He joined Tufts inSeptember, 2010. His current researchinterests lie at the intersection of material science engineering, specificallymicro/nanoscience, and biomedical application. His work involves usingcombinatorial method to develop novel materials for the delivery of therapeuticbiomacromolecules and using nanotechnology to develop novel biomaterials fortissue engineering. He received Charlton Award from Tufts University School ofMedicine in 2012 and named the Pew Scholar for Biomedical Sciences from PewCharitable Trusts in 2013. He received the National Science Foundation CAREERAward in 2015.
Contact:Prof. Lichen Yin
