Presenter：Prof. Marie-Louise Saboungi, 法国奥尔良大学,皮埃尔与玛丽・居里大学,法国国家科学研究中心
Topic：SUPERPARAMAGNETIC NANOPARTICLES IN BIOLOGY AND MEDICINE
Time：10:10 AM, Oct. 21st(Friday)
Location：909-B
Abstract
Recent years have seen heightenedapplications of magnetic nanoparticles (NPs) in biomedicine. Most of theseinvolve iron oxide nanoparticles in the superparamagnetic (SPM) state, in whichthe particles behave as paramagnets with a huge magnetic moment.1-6 The applicationscan be roughly divided into three groups:
1. Imaging using magnetic nanoparticles, whereSPM NPs are used as contrast agents in magnetic resonance imaging because oftheir large magnetic moments in a static magnetic field.
2. Magnetic targeting for drug and gene delivery,which can be effected in a number of different ways: a) thermomagnetic activation,in which fast relaxation of SPM NPs leads to local heating and hence drug orgene release; b) Direct magnetic activation with a rotating magnetic field; andc) magnetic guiding to critical locations with an strong external magnetic field.
3. Hyperthermia therapy, which, between 40 and43° C, stimulates the immune system of the patient for an anticancer response,generally associated with radiotherapy or chemotherapy.
In this talk I will briefly summarizeprogress in these areas and proceed to a more detailed discussion of twoavenues recently explored.
References
1) K. Hervé, et al Nanotechnology 19, 465608(2008).
2) K. Kaaki, et al Langmuir 28, 1496 (2012).
3) J. Gautier, et al Int. J. Pharm. 423,16.(2012).
4) I. Milosevic, et al Appl. Phys. Letters104, 043701 (2014); T. Marin et al Appl. Phys. Letters 106 , 183706 (2015)
5) H. Khurshid et al, Scientific Reports,Scientific Reports, 5, 15054, 2015
6) I. Milosevic, et al, Biochemica etBioPhysica Acta General Subjects, in press
Biography
Marie-Louise Saboungi isProfessor of Condensed Matter Physics at the French Universities and conductsher research at the CNRS and the Pierre et Marie Curie University, Paris andFUNSOM in Suchou, China. She is a Fellow of APS, AAAS, and Alexander vonHumboldt Foundation from whichshe received the Helmholtz-Humboldt Prize. She served as Director of a researchinstitute in Orleans (CRMD) and as Co-Director of the Materials, Energy and Geosciences Thrust Areaat the University of Orleans. Prior to that she was a Senior Scientist at ArgonneNational Laboratory with close collaborations with the U of C’s James FranckInstitute and with Cornell University. She has served on national committeesfor DOE and NSF, in France for the CNRS, ANR and AERES, and in the EuropeanCommunity where she served on the FET Advisory Board for Horizon 2020. She hasorganized and chaired over fifty international conferences and workshopsincluding two Gordon Research Conferences. She actively participated in theAssociation of Women in Science and received an Award for Leadership from theYWCA of Metropolitan Chicago. At present she is involved in investigatingcomplex soft materials with a special interest in the thermal, magnetic andbiomedical properties of functionalized nanomaterials with a view toapplications in energy and biotechnology.
Contact: Rui Peng
（责任编辑：张伶 联系方式：zhangling10@suda.edu.cn）
