Presenter：Prof. Shawn Li, Ph.D (李顺成) WesternUniversity

Topic：FunctionalProteomics for Precision Cancer Medicine

Time：10 :00 AM, October26, 2016

Location：910-308

Abstract：

Proteins in the cell are subjected to numerous post-translationalmodifications (PTM). PTMs not only greatly increase the size of the proteome,they also enrich protein function and enable dynamic control of essentialcellular processes such as proliferation, differentiation, and apoptosis. Weare interested in understanding the mechanism of signal transduction mediatedby protein phosphorylation and methylation in cells under normal orpathological conditions. A major focus of my lab is to identify novel tyrosinephosphorylation and lysine methylation sites and to characterize their functionsin tumorigenesis and drug resistance. By combining proteomic techniques such asmass spectrometry and peptide/protein microarrays with conventionalbiochemical, molecular, and cellular approaches, we hope to uncover novel PTMevents in an effective and systematic manner, generate new insights intodisease mechanism, and develop innovative strategies for the accurate diagnosisand precise treatment of complex human diseases such as cancer.

PROFESSIONALEXPERIENCE

2011-present             Professor,Department of Biochemistry, UWO.

2005-2010          AssociateProfessor, Department of Biochemistry, UWO.

2000-2005          Assistant Professor, Department ofBiochemistry, UWO.

2000-present             Scientist,Lawson Health Research Institute, UWO

SELECTEDPUBLICATIONS

Shawn S-C Li*et al., Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosinesuperbinder. NatureChemical Biology 2016, (in press)

Shawn S-C Li*et al., A phosphorylation switch controls the spatiotemporal activation of RhoGTPases in directional cell migration. NatureCommunications. 2015, 6:7721

Shawn S-C Li*et al., A Comprehensive Immunoreceptor Phosphotyrosine-based Signaling NetworkRevealed by Reciprocal Protein�Peptide Array Screening. Molecular & Cellular Proteomics. 2015, 14:1846-58.

Shawn S-C Li*et al., Non-histone protein methylation as a regulator of cellular signaltransduction.  NatRev Mol Cell Biol 2015,16(1):5-17

Shawn S-C Li*et al., A Method for Systematic Mapping of Protein Lysine MethylationIdentifies Functions for HP1beta in DNA Damage Response Mol. Cell 2013;50(5):723-35.

Shawn S-C Li*et al., Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci. Signal. 2012, 243, ra68

Shawn S-C Li*et al., Differential regulation of the activity of deleted in liver cancer 1(DLC1) by tensins controls cell migration and transformation. PNAS 2012;109(5):1455-60

Contact: Prof.Jian Liu

（责任编辑：张伶  邮箱：zhangling10@suda.edu.cn）