报告人： Prof. Wei R. Chen, University of Central Oklahoma
报告题目：Nanotechnology-basedphotoimmunotherapy for treatment of metastatic cancers
报告时间：15：00 PM, Sep. 25th (Monday)
报告地点：909-B
Abstract
Cancer has been a leading cause of death since the beginning of humanhistory. Various therapies have beendeveloped, yet cancer remains to be one of the biggest medical challenges forresearchers and clinicians, largely due to tumor metastasis. To target the rootcause of cancer, we developed laser immunotherapy (LIT). LIT uses thecombination of local laser irradiation and immunotherapy to inducetumor-specific immune responses. In our pre-clinical and preliminary clinicalstudies, LIT is shown to be highly effective against metastatic tumors. Theexperimental results indicated a systemic, long-term anti-tumor immunologicalresponse induced by LIT, using the entire tumor cell as the sources of tumorantigens, based on the principle of in situ autologous whole-cell cancer vaccination.With our efforts during the past 20 years, LIT has been developed from a simplebench-top concept to a potential bedside clinical tool, with extremelypromising outcomes in our preliminary clinical trials for melanoma and breastcancer patients. To further improve LIT, we developed nanotechnology-basednovel photoimmunotherapy using immunologically modified nanotubes, with a novelimmunoadjuvant as their effective surfactant. The modified nanotubes serves asa spatial-temporal continuum to provide synergistic, synchronized photothermaland immunological interactions, when administered to target tumors, followed bylaser irradiation. This nanotechnology-based photoimmunotherapy has showedpromise in treating metastatic tumors in animal models. This talk will introduce to the audience thedevelopment of LIT, its preliminary clinical results, and the development ofnanotechnology-based photoimmunotherapy for the treatment of metastaticcancers.
Biography
Wei R. Chen received his BS in physics fromShandong University in China in 1982, and Ph.D. degree in theoreticalhigh-energy physics from the University of Oregon in 1988. Currently he is Professor at the University of Central Oklahoma, Edmond, Oklahoma, United States.Dr. Chen’ s research focuses on cancer treatment. He is the co-inventor(awarded 5 US patents) of the novel treatment method for metastaticcancers-laser immunotherapy (LIT). Dr. Chen has an outstanding teaching careerfor more than 30 years. He received the 2008 US Professor of the Year award,the highest national award for excellence in teaching in the United States. Hewas the recipient of the 2011-2012 US Fulbright Lecturing / Research Award. Hewas the winner of the Medal for Excellence in Teaching from the Oklahoma Foundationfor Excellence, the highest teaching award in the State of Oklahoma. In 2012,Dr. Chen received the international recognition as the recipient of the SPIEEducator Award.
Contact: Prof. Zhuang Liu
责任编辑：杨娟
