题目：

Mn2+-Doped Prussian Blue Nanocubes for Bimodal Imaging and Photothermal Therapy with Enhanced Performance

作者：

Wenwen Zhu,^†,‡ Kai Liu,^†,‡ Xiaoqi Sun,^‡ Xin Wang,^§ Yonggang Li,^§ Liang Cheng,^*,‡ and Zhuang Liu^‡

单位：

^‡Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China

^§Department of Radiology the First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China

摘要：

Prussian blue (PB) as a clinically adapted agent recently has drawn much attention in cancer theranostics for potential applications in magnetic resonance (MR) imaging as well as photothermal cancer treatment. In this work, we take a closer look at the imaging and therapy performance of PB agents once they are doped with Mn2+. It is found that Mn2+-doped PB nanocubes exhibit increased longitudinal relaxivity along with enhanced optical absorption red-shifted to the near-infrared (NIR) region. Those properties make PB:Mn nanocubes with appropriate surface coatings rather attractive agents for biomedical imaging and cancer therapy, which have been successfully demonstrated in our in vivo experiments for effectively tumor ablation.

影响因子：

5.900

分区情况：

1区

链接：

http://pubs.acs.org/doi/full/10.1021/acsami.5b02510