题目：

Nanoscale theranostics for physical stimulus-responsive cancer therapies

作者：

Qian Chen ^a, Hengte Ke ^b, Zhifei Dai ^c, **, Zhuang Liu ^a, *

单位：

^aInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China

^bCollege of Pharmaceutical Sciences, Soochow University, Suzhou, 215123 Jiangsu, China

^cDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China

摘要：

Physical stimulus-responsive therapies often employing multifunctional theranostic agents responsive to external physical stimuli such as light, magnetic field, ultra-sound, radiofrequency, X-ray, etc., have been widely explored as novel cancer therapy strategies, showing encouraging results in many pre-clinical animal experiments. Unlike conventional cancer chemotherapy which often accompanies with severe toxic side effects, physical stimulus-responsive agents usually are non-toxic by themselves and would destruct cancer cells only under specific external stimuli, and thus could offer greatly reduced toxicity and enhanced treatment specificity. In addition, physical stimulus-responsive therapies can also be combined with other traditional therapeutics to achieve synergistic anti-tumor effects via a variety of mechanisms. In this review, we will summarize the latest progress in the development of physical stimulus-responsive therapies, and discuss the important roles of nanoscale theranostic agents involved

in those non-conventional therapeutic strategies.

影响因子：

8.312

分区情况：

1区

链接：

http://www.sciencedirect.com/science/article/pii/S0142961215007632