题目：

Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures

作者：

Yu Yang¹, Jingjing Liu², Xiaoqi Sun², Liangzhu Feng², Wenwen Zhu², Zhuang Liu² and Meiwan Chen¹

单位：

¹State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China

²Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou 215123, China

摘要：

Stimuli-activated targeted delivery systems for highly accurate treatment of tumors have received considerable attention in recent years. Herein, we reveal a light-activable cancer-targeting strategy that uses a complementary DNA sequence to hybridize and mask sgc8 aptamers conjugated onto photothermal agents such as gold nanorods or single-walled carbon nanotubes (SWNTs). Upon exposure to near-infrared (NIR) laser, localized photothermal heating of the surface of those nano-agents results in dehybridization of the double-stranded DNA and uncaging of the aptamer sequence to allow specific cancer-cell targeting. Utilizing doxorubicin-loaded SWNTs as a model system, targeted drug delivery to cancer cells activated by NIR light was achieved. This work demonstrates the concept of NIR-activable tumor-targeting delivery systems with controllable cancer-cell binding to potentially enable highly specific and efficient cancer therapy.

影响因子：

7.010

分区情况：

1区

链接：

http://link.springer.com/article/10.1007/s12274-015-0898-4