题目：

Dual-Modality Positron Emission Tomography/Optical Image-Guided Photodynamic Cancer Therapy with Chlorin e6-Containing Nanomicelles

作者：

Liang Cheng,*^,†,‡ Anyanee Kamkaew,^‡ Haiyan Sun,^‡ Dawei Jiang,^‡ Hector F. Valdovinos,^§ Hua Gong,^† Christopher G. England,^§ Shreya Goel,^∥ Todd E. Barnhart,^§ and Weibo Cai*^,‡,§,∥

单位：

  摘要：      

^†Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China

^‡Department of Radiology, ^§Department of Medical Physics, and ^∥Materials Science Program, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States

We develop an organic photodynamic therapy (PDT) system based on polyethylene glycol (PEG)-coated nanomicelles conjugated with ∼20% chlorin e6 (PEG-Ce6 nanomicelles), which functions as an optical imaging agent, as well as a PDT agent. The formed PEG-Ce6 nanomicelles with the size of ∼20 nm were highly stable in various physiological solutions for a long time. Moreover, Ce6 can also be a 64Cu chelating agent for in vivo positron emission tomography (PET). By simply mixing, more than 90% of ⁶⁴Cu was chelator-free labeled on PEG-Ce6 nanomicelles, and they also showed high stability in serum conditions. Both fluorescence imaging and PET imaging revealed that PEG-Ce6 nanomicelles displayed high tumor uptake (13.7 ± 2.2%ID/g) after intravenous injection into tumor-bearing mice at the 48 h time point. In addition, PEG-Ce6 nanomicelles exhibited excellent PDT properties upon laser irradiation, confirming the theranostic properties of PEG-Ce6 nanomicelles for imaging and treatment of cancer. In addition, PDT was not shown to render any appreciable toxicity.

影响因子：

13.334

分区情况：

一区

链接：

http://pubs.acs.org/doi/abs/10.1021/acsnano.6b03074