题目：

CaCO₃ nanoparticles as an ultra-sensitive tumor-pH-responsive nanoplatform enabling real-time drug release monitoring and cancer combination therapy

作者：

Ziliang Dong^a, Liangzhu Fen^{a, *}, Wenwen Zhu^a, Xiaoqi Sun^a, Min Gao^a, He Zhao^b, Yu Chao^a, Zhuang Liu^{a, *}

单位：

摘要：      

^a Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, PR China

^b Department of Radiology, Children's Hospital of Soochow University, Suzhou, 215003, Jiangsu, PR China

We develop mono-dispersed CaCO₃ nanoparticles modified with polyethylene glycol (PEG) as a multifunctional nano-carrier for efficient loading of both Mn²⁺-chelated chlorin e6 (Ce6(Mn)) as a photosensitizer, and doxorubicin (DOX) as a chemotherapy drug. Our CaCO₃@Ce6(Mn)-PEG(DOX) nanoparticles, while being stable under physiological pH at 7.4, appear to be highly sensitive to reduced pH and would be rapidly degraded under slightly acidic environment, effectively releasing loaded therapeutic agents. Interestingly, owing to released Ce6(Mn), those nanoparticles show an interesting pH-dependent T1 signal enhancement under magnetic resonance (MR) imaging, which could be utilized for real-time monitoring of drug release. As discovered by MR and fluorescence imaging, intravenously (i.v.) injected CaCO₃@Ce6(Mn)/DOX-PEG could gradually accumulate in the tumor, contributing to a superior synergistic anti-tumor effect in the combined photodynamic & chemotherapy. In conclusion, we have developed a tumor-pH-activated nanocarrier based on biodegradable CaCO₃ nanoparticles, which may be an ideal cancer theranostic nanoplatform with substantial potential for future clinical translation.

影响因子：

8.387

分区情况：

一区

链接：

http://www.sciencedirect.com/science/article/pii/S0142961216305233