题目：

Concentrations dominated membrane permeability variation by fullerol nanoparticles on a single living HeLa cell

作者：

Naiyun Liu,^a Mumei Han,^a Yalin Zhang,^a Xiuqin Wu,^a Juan Liu,^a Hao Li,^a Tiantian Cao,^b Xueyan Nan,^a Hui Huang,*^a Yang Liu,*^a Ning Chen,^b Chunru Wang^c and Zhenhui Kang*^a

单位：

^a Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, China.

^b Laboratory of Advanced Optoelectronic Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China

^c Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

摘要：

The effects in HeLa cell membrane permeability caused by the fullerenols C₆₀(OH)_n with different concentrations were studied by scanning electrochemical microscopy (SECM). We demonstrate that C₆₀(OH)_n has very low cytotoxicity, although it can still have strong effects on the cell membrane permeability. In the presence of 1×10^-3 mg mL^-1 (1 ppm) C₆₀(OH)_n, the cell membrane permeability increases by 26% after 76 min, which is reversible. When C₆₀(OH)_n concentration is over 25×10^-3 mg mL^-1 (25 ppm), the change in membrane permeability (increased 19%) is irreversible.

影响因子：

4.872

分区情况：

一区 

链接： 

http://pubs.rsc.org/en/content/articlelanding/2016/tb/c6tb01474g#!divAbstract